Spirochete Flagella and Motility.
chemotaxis
molecular motor
motility
periplasmic flagella
spirochetes
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
04 04 2020
04 04 2020
Historique:
received:
11
03
2020
revised:
03
04
2020
accepted:
03
04
2020
entrez:
9
4
2020
pubmed:
9
4
2020
medline:
30
3
2021
Statut:
epublish
Résumé
Spirochetes can be distinguished from other flagellated bacteria by their long, thin, spiral (or wavy) cell bodies and endoflagella that reside within the periplasmic space, designated as periplasmic flagella (PFs). Some members of the spirochetes are pathogenic, including the causative agents of syphilis, Lyme disease, swine dysentery, and leptospirosis. Furthermore, their unique morphologies have attracted attention of structural biologists; however, the underlying physics of viscoelasticity-dependent spirochetal motility is a longstanding mystery. Elucidating the molecular basis of spirochetal invasion and interaction with hosts, resulting in the appearance of symptoms or the generation of asymptomatic reservoirs, will lead to a deeper understanding of host-pathogen relationships and the development of antimicrobials. Moreover, the mechanism of propulsion in fluids or on surfaces by the rotation of PFs within the narrow periplasmic space could be a designing base for an autonomously driving micro-robot with high efficiency. This review describes diverse morphology and motility observed among the spirochetes and further summarizes the current knowledge on their mechanisms and relations to pathogenicity, mainly from the standpoint of experimental biophysics.
Identifiants
pubmed: 32260454
pii: biom10040550
doi: 10.3390/biom10040550
pmc: PMC7225975
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 18K07100
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : 15H01307
Pays : International
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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