Core outcome set in paediatric sepsis in low- and middle-income countries: a study protocol.
community child health
neonatal intensive & critical care
paediatric infectious disease & immunisation
paediatric intensive & critical care
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
06 04 2020
06 04 2020
Historique:
entrez:
9
4
2020
pubmed:
9
4
2020
medline:
4
3
2021
Statut:
epublish
Résumé
Sepsis is the leading cause of death in children worldwide and has recently been declared a major global health issue. New interventions and a concerted effort to enhance our understanding of sepsis are required to address the huge burden of disease, especially in low- and middle-income countries (LMIC) where it is highest. An opportunity therefore exists to ensure that ongoing research in this area is relevant to all stakeholders and is of consistently high quality. One method to address these issues is through the development of a core outcome set (COS). This study protocol outlines the phases in the development of a core outcome set for paediatric sepsis in LMIC. The first step involves performing a systematic review of all outcomes reported in the research of paediatric sepsis in low middle-income countries. A three-stage international Delphi process will then invite a broad range of participants to score each generated outcome for inclusion into the COS. This will include an initial two-step online survey and finally, a face-to-face consensus meeting where each outcome will be reviewed, voted on and ratified for inclusion into the COS. No core outcome sets exist for clinical trials in paediatric sepsis. This COS will serve to not only highlight the heavy burden of paediatric sepsis in this setting and aid collaboration and participation between all stakeholders, but to promote ongoing essential high quality and relevant research into the topic. A COS in paediatric sepsis in LMIC will advocate for a common language and facilitate interpretation of findings from a variety of settings. A waiver for ethics approval has been granted by University of British Columbia Children's and Women's Research Ethics Board.
Identifiants
pubmed: 32265242
pii: bmjopen-2019-034960
doi: 10.1136/bmjopen-2019-034960
pmc: PMC7245395
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e034960Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
PLoS Med. 2017 Nov 16;14(11):e1002447
pubmed: 29145404
J Clin Epidemiol. 2014 Jul;67(7):745-53
pubmed: 24582946
Trials. 2016 Sep 13;17(1):449
pubmed: 27618914
Lancet Respir Med. 2018 Mar;6(3):223-230
pubmed: 29508706
PLoS Med. 2016 Oct 18;13(10):e1002148
pubmed: 27755541
Trials. 2017 Jun 20;18(Suppl 3):280
pubmed: 28681707
J Clin Epidemiol. 2018 Apr;96:84-92
pubmed: 29288712
BMJ Open. 2017 Jun 9;7(6):e016146
pubmed: 28601837
PLoS Med. 2008 Apr 29;5(4):e96
pubmed: 18447577
Trials. 2015 Dec 02;16:545
pubmed: 26625730
Trials. 2012 Aug 06;13:132
pubmed: 22867278
J Clin Epidemiol. 2011 Apr;64(4):395-400
pubmed: 21194891
Am J Respir Crit Care Med. 2015 May 15;191(10):1147-57
pubmed: 25734408
Curr Opin Crit Care. 2018 Oct;24(5):421-427
pubmed: 30045088
Trials. 2014 May 13;15:168
pubmed: 24885068
PLoS One. 2018 Dec 28;13(12):e0209869
pubmed: 30592741
Trials. 2007 Nov 26;8:39
pubmed: 18039365
J Infect. 2015 Jun;71 Suppl 1:S21-6
pubmed: 25917800
Trials. 2013 Mar 12;14:70
pubmed: 23497540
PLoS One. 2008 Aug 28;3(8):e3081
pubmed: 18769481
BMJ. 2010 Feb 15;340:c365
pubmed: 20156912
Trials. 2019 Feb 11;20(1):116
pubmed: 30744706
J Clin Epidemiol. 2009 Oct;62(10):1006-12
pubmed: 19631508
Pediatr Crit Care Med. 2017 Mar;18(3):e146-e154
pubmed: 28099233
JAMA Pediatr. 2019 Apr 1;173(4):352-362
pubmed: 30742207
PLoS One. 2015 Jan 24;10(1):e0116949
pubmed: 25617837