Investigation of pathology, expression and proteomic profiles in human TREM2 variant postmortem brains with and without Alzheimer's disease.
APOE
Alzheimer’s disease
TREM2
amyloid
microglia
multiomics
neuroinflammation
tau
Journal
Brain pathology (Zurich, Switzerland)
ISSN: 1750-3639
Titre abrégé: Brain Pathol
Pays: Switzerland
ID NLM: 9216781
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
13
02
2020
revised:
11
03
2020
accepted:
26
03
2020
pubmed:
9
4
2020
medline:
23
6
2021
entrez:
9
4
2020
Statut:
ppublish
Résumé
Triggering receptor expressed on myeloid cells 2 TREM2 was identified as a risk factor for late onset Alzheimer's disease (AD). Here we compared TREM2 cases with a variant (TREM2
Identifiants
pubmed: 32267026
doi: 10.1111/bpa.12842
pmc: PMC8018003
doi:
Substances chimiques
Amyloid beta-Peptides
0
Membrane Glycoproteins
0
Receptors, Immunologic
0
TREM2 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
794-810Subventions
Organisme : Alzheimer's Research UK
ID : ARUK-PhD2014-5
Pays : International
Organisme : Michael J Fox Foundation
Pays : International
Organisme : Leonard Wolfson Centre for Experimental Neurology
Pays : International
Organisme : Reta Lila Weston Institute for Neurological Studies
Pays : International
Organisme : UK Dementia Research Institute
Pays : International
Organisme : National Institute for Health Research
Pays : International
Organisme : Queen Square Biomedical Research Unit
Pays : International
Organisme : University College London
Pays : International
Organisme : Medical Research Council
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.
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