Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques.
Animals
Antibodies, Neutralizing
/ blood
Antibodies, Viral
/ blood
Dengue
/ immunology
Dengue Virus
/ physiology
Disease Models, Animal
Female
Kinetics
Macaca mulatta
/ immunology
Mosquito Vectors
/ virology
RNA, Viral
/ blood
Salivary Glands
/ virology
Vaccination
Viral Load
Viremia
/ prevention & control
Virus Replication
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
22
08
2019
accepted:
02
03
2020
entrez:
9
4
2020
pubmed:
9
4
2020
medline:
7
7
2020
Statut:
epublish
Résumé
Dengue virus (DENV) is transmitted by infectious mosquitoes during blood-feeding via saliva containing biologically-active proteins. Here, we examined the effect of varying DENV infection modality in rhesus macaques in order to improve the DENV nonhuman primate (NHP) challenge model. NHPs were exposed to DENV-1 via subcutaneous or intradermal inoculation of virus only, intradermal inoculation of virus and salivary gland extract, or infectious mosquito feeding. The infectious mosquito feeding group exhibited delayed onset of viremia, greater viral loads, and altered clinical and immune responses compared to other groups. After 15 months, NHPs in the subcutaneous and infectious mosquito feeding groups were re-exposed to either DENV-1 or DENV-2. Viral replication and neutralizing antibody following homologous challenge were suggestive of sterilizing immunity, whereas heterologous challenge resulted in productive, yet reduced, DENV-2 replication and boosted neutralizing antibody. These results show that a more transmission-relevant exposure modality resulted in viral replication closer to that observed in humans.
Identifiants
pubmed: 32267846
doi: 10.1371/journal.pntd.0008191
pii: PNTD-D-19-01422
pmc: PMC7141610
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0008191Déclaration de conflit d'intérêts
I have read the journal's policy and the authors of this manuscript have the following competing interests: Yannick Vanloubbeeck, Clarisse Lorin, Marie-Pierre Malice, David Vaughn, and Lucile Warter are employees of the GSK group of companies.
Références
PLoS Pathog. 2007 Sep 14;3(9):1262-70
pubmed: 17941708
Sci Transl Med. 2016 Mar 16;8(330):330ra36
pubmed: 27089205
Am J Trop Med Hyg. 2011 Jun;84(6):978-87
pubmed: 21633037
Lancet Infect Dis. 2016 Jun;16(6):712-723
pubmed: 26874619
N Engl J Med. 2018 Jul 26;379(4):327-340
pubmed: 29897841
J Infect Dis. 1979 Oct;140(4):527-33
pubmed: 117061
Med Vet Entomol. 2004 Jun;18(2):191-9
pubmed: 15189245
Vaccine. 2010 Mar 24;28(15):2705-15
pubmed: 20097152
Virology. 2014 Mar;452-453:237-46
pubmed: 24606701
J Infect Dis. 1973 Jul;128(1):23-30
pubmed: 4198025
Lancet. 2014 Oct 11;384(9951):1358-65
pubmed: 25018116
J Infect Dis. 1973 Jul;128(1):15-22
pubmed: 4198024
Clin Infect Dis. 2004 Dec 15;39(12):1818-23
pubmed: 15578405
J Med Entomol. 1998 May;35(3):261-5
pubmed: 9615544
J Med Entomol. 2003 Mar;40(2):199-205
pubmed: 12693849
J Gen Virol. 2009 Nov;90(Pt 11):2660-2668
pubmed: 19641044
J Virol. 2018 May 29;92(12):
pubmed: 29593041
Southeast Asian J Trop Med Public Health. 1996 Dec;27(4):664-72
pubmed: 9253864
Am J Trop Med Hyg. 2012 Sep;87(3):504-10
pubmed: 22848099
Vaccine. 2003 Oct 1;21(27-30):4307-16
pubmed: 14505913
J Virol. 2012 Jul;86(14):7637-49
pubmed: 22573866
Parasite Immunol. 1999 Jan;21(1):35-44
pubmed: 10081770
PLoS Negl Trop Dis. 2012;6(11):e1905
pubmed: 23166852
Am J Trop Med Hyg. 1996 Apr;54(4):338-42
pubmed: 8615443
Am J Trop Med Hyg. 1992 Aug;47(2):190-4
pubmed: 1503187
J Virol. 2004 May;78(9):4761-75
pubmed: 15078958
N Engl J Med. 2015 Jan 8;372(2):113-23
pubmed: 25365753
J Virol. 2014 Feb;88(4):1881-9
pubmed: 24198426
Am J Trop Med Hyg. 2015 Apr;92(4):698-708
pubmed: 25646261
PLoS Negl Trop Dis. 2018 May 17;12(5):e0006439
pubmed: 29771921
PLoS One. 2013 Dec 02;8(12):e81211
pubmed: 24312537
Am J Trop Med Hyg. 2013 Dec;89(6):1043-57
pubmed: 24062475
Front Immunol. 2014 Sep 24;5:452
pubmed: 25309540
PLoS Pathog. 2017 Aug 3;13(8):e1006487
pubmed: 28771605
Science. 2017 Mar 24;355(6331):1302-1306
pubmed: 28336667
Ann Trop Med Parasitol. 1952 Dec;46(4):311-9
pubmed: 13008362
Lancet. 2015 Jan 31;385(9966):453-65
pubmed: 25230594
Parasite Immunol. 2012 Jan;34(1):15-22
pubmed: 21995849
BMC Genomics. 2007 Jan 04;8:6
pubmed: 17204158
Pathog Glob Health. 2018 Sep;112(6):334-341
pubmed: 30246621
J Infect Dis. 2013 Mar 1;207(5):700-8
pubmed: 23225894
Virology. 2014 Nov;468-470:133-139
pubmed: 25173089
J Virol. 2011 Feb;85(4):1517-27
pubmed: 21147918
J Virol. 2014 Jan;88(1):164-75
pubmed: 24131723
Am J Trop Med Hyg. 2008 Mar;78(3):370-4
pubmed: 18337328
PLoS One. 2007 Nov 14;2(11):e1171
pubmed: 18000543
PLoS One. 2010 Jul 22;5(7):e11704
pubmed: 20661470
J Invest Dermatol. 2012 Aug;132(8):2103-5
pubmed: 22475758
Virology. 2010 Jan 20;396(2):280-8
pubmed: 19913867
J Biomed Sci. 2001 Sep;8(5):377-88
pubmed: 11549879
PLoS One. 2010 Aug 12;5(8):e12137
pubmed: 20711354
Malays J Pathol. 2015 Dec;37(3):247-51
pubmed: 26712670
Clin Microbiol Rev. 1998 Jul;11(3):480-96
pubmed: 9665979
J Biomed Sci. 2013 Oct 20;20:75
pubmed: 24138072
Parasit Vectors. 2014 May 30;7:252
pubmed: 24886023
PLoS Negl Trop Dis. 2016 Sep 15;10(9):e0004941
pubmed: 27632170
PLoS Negl Trop Dis. 2012;6(2):e1487
pubmed: 22363823
Viral Immunol. 2006 Spring;19(1):74-82
pubmed: 16553552
Trans R Soc Trop Med Hyg. 2008 May;102(5):400-8
pubmed: 18342898
J Med Entomol. 1995 Jul;32(4):563-8
pubmed: 7650720
PLoS Pathog. 2019 Apr 22;15(4):e1007721
pubmed: 31009499
Front Microbiol. 2013 Oct 11;4:305
pubmed: 24130557
Blood. 2010 Mar 4;115(9):1823-34
pubmed: 20042723
Am J Trop Med Hyg. 2001 Nov;65(5):405-13
pubmed: 11716091
Viral Immunol. 2004;17(4):565-73
pubmed: 15671753
Am J Trop Med Hyg. 2006 Aug;75(2):337-45
pubmed: 16896145
Vaccine. 2008 Feb 6;26(6):817-28
pubmed: 18191005
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
J Clin Virol. 2015 Feb;63:25-31
pubmed: 25600599
PLoS Pathog. 2016 Jun 16;12(6):e1005676
pubmed: 27310141
Proc Natl Acad Sci U S A. 2007 May 29;104(22):9422-7
pubmed: 17517625
Rev Bras Hematol Hemoter. 2012;34(1):36-41
pubmed: 23049382
J Infect Dis. 2014 Jun 15;209 Suppl 2:S71-8
pubmed: 24872400
Vaccine. 2015 Dec 10;33(50):7075-82
pubmed: 26424605
J Infect Dis. 1973 Jul;128(1):7-14
pubmed: 4198027
Parasite Immunol. 2000 Sep;22(9):461-7
pubmed: 10972853
Am J Trop Med Hyg. 2014 Oct;91(4):672-6
pubmed: 25092823
Am J Trop Med Hyg. 1976 Jan;25(1):146-50
pubmed: 3980
Trends Parasitol. 2017 Aug;33(8):645-657
pubmed: 28495485
PLoS One. 2018 Apr 25;13(4):e0196311
pubmed: 29694440