Respiratory pathogens and acute chest syndrome in children with sickle cell disease.
Acute Chest Syndrome
/ etiology
Adenoviridae
Adenoviridae Infections
/ diagnosis
Anemia, Sickle Cell
/ complications
Case-Control Studies
Child, Preschool
Female
Humans
Male
Multiplex Polymerase Chain Reaction
Mycoplasma pneumoniae
Paramyxoviridae Infections
/ diagnosis
Picornaviridae Infections
/ diagnosis
Pneumonia, Mycoplasma
/ diagnosis
Prospective Studies
Respiratory Syncytial Virus Infections
/ diagnosis
Respiratory Syncytial Viruses
Rhinovirus
epidemiology
general paediatrics
haematology
infectious diseases
virology
Journal
Archives of disease in childhood
ISSN: 1468-2044
Titre abrégé: Arch Dis Child
Pays: England
ID NLM: 0372434
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
27
03
2019
revised:
15
03
2020
accepted:
16
03
2020
pubmed:
10
4
2020
medline:
21
10
2020
entrez:
10
4
2020
Statut:
ppublish
Résumé
Acute chest syndromes (ACS) may be associated with upper respiratory tract infections, but the epidemiology of viral and intracellular respiratory pathogens in children with sickle cell disease (SCD) is not precisely known. The aim of this study was to describe the epidemiology of viral and intracellular respiratory pathogens in children with SCD presenting with fever and/or ACS. An observational, prospective, single-centre cohort study with nested case-control analysis was conducted on children with SCD admitted from October 2016 to October 2017 for fever and/or ACS to the paediatric department of Robert Debré university hospital, Paris, France. They were screened for 20 respiratory pathogens by a multiplex PCR in the nasopharynx (FilmArray). We included 101 children. M/F sex ratio of 0.45. The median age was 3.2 years (IQR: 1.4-8.2). At least one pathogen was isolated in 67 patients (67%). The most frequent viruses were as follows: rhinovirus (n=33), adenovirus (n=14), respiratory syncytial virus (n=13) and parainfluenza viruses (n=11). Viral detection in febrile children with SCD is frequent, but its association with ACS was not demonstrated. In this study,
Sections du résumé
BACKGROUND
Acute chest syndromes (ACS) may be associated with upper respiratory tract infections, but the epidemiology of viral and intracellular respiratory pathogens in children with sickle cell disease (SCD) is not precisely known. The aim of this study was to describe the epidemiology of viral and intracellular respiratory pathogens in children with SCD presenting with fever and/or ACS.
MATERIALS AND METHODS
An observational, prospective, single-centre cohort study with nested case-control analysis was conducted on children with SCD admitted from October 2016 to October 2017 for fever and/or ACS to the paediatric department of Robert Debré university hospital, Paris, France. They were screened for 20 respiratory pathogens by a multiplex PCR in the nasopharynx (FilmArray).
RESULTS
We included 101 children. M/F sex ratio of 0.45. The median age was 3.2 years (IQR: 1.4-8.2). At least one pathogen was isolated in 67 patients (67%). The most frequent viruses were as follows: rhinovirus (n=33), adenovirus (n=14), respiratory syncytial virus (n=13) and parainfluenza viruses (n=11).
CONCLUSIONS
Viral detection in febrile children with SCD is frequent, but its association with ACS was not demonstrated. In this study,
Identifiants
pubmed: 32269038
pii: archdischild-2019-317315
doi: 10.1136/archdischild-2019-317315
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
891-895Informations de copyright
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.