Venlafaxine Stimulates an MMP-9-Dependent Increase in Excitatory/Inhibitory Balance in a Stress Model of Depression.
Adult
Aged
Animals
Cells, Cultured
Cerebral Cortex
/ drug effects
Depressive Disorder, Major
/ drug therapy
Female
Gamma Rhythm
Humans
Male
Matrix Metalloproteinase 9
/ genetics
Memory, Short-Term
Mice
Mice, Inbred C57BL
Middle Aged
Neural Inhibition
Pyramidal Cells
/ metabolism
Serotonin and Noradrenaline Reuptake Inhibitors
/ pharmacology
Stress, Psychological
/ complications
Venlafaxine Hydrochloride
/ pharmacology
MMP
MMP-9
depression
parvalbumin
perineuronal net
venlafaxine
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
27 05 2020
27 05 2020
Historique:
received:
04
10
2019
revised:
19
03
2020
accepted:
20
03
2020
pubmed:
10
4
2020
medline:
23
10
2020
entrez:
10
4
2020
Statut:
ppublish
Résumé
Emerging evidence suggests that there is a reduction in overall cortical excitatory to inhibitory balance in major depressive disorder (MDD), which afflicts ∼14%-20% of individuals. Reduced pyramidal cell arborization occurs with stress and MDD, and may diminish excitatory neurotransmission. Enhanced deposition of perineuronal net (PNN) components also occurs with stress. Since parvalbumin-expressing interneurons are the predominant cell population that is enveloped by PNNs, which enhance their ability to release GABA, excess PNN deposition likely increases pyramidal cell inhibition. In the present study, we investigate the potential for matrix metalloprotease-9 (MMP-9), an endopeptidase secreted in response to neuronal activity, to contribute to the antidepressant efficacy of the serotonin/norepinephrine reuptake inhibitor venlafaxine in male mice. Chronic venlafaxine increases MMP-9 levels in murine cortex, and increases both pyramidal cell arborization and PSD-95 expression in the cortex of WT but not MMP-9-null mice. We have previously shown that venlafaxine reduces PNN deposition and increases the power of
Identifiants
pubmed: 32269106
pii: JNEUROSCI.2387-19.2020
doi: 10.1523/JNEUROSCI.2387-19.2020
pmc: PMC7252486
doi:
Substances chimiques
Serotonin and Noradrenaline Reuptake Inhibitors
0
Venlafaxine Hydrochloride
7D7RX5A8MO
Matrix Metalloproteinase 9
EC 3.4.24.35
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4418-4431Subventions
Organisme : NIMH NIH HHS
ID : R21 MH118749
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS041218
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM103328
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121334
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH067996
Pays : United States
Informations de copyright
Copyright © 2020 the authors.
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