Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production.
Animals
Cell Differentiation
Cornified Envelope Proline-Rich Proteins
/ genetics
Epithelial-Mesenchymal Transition
Gene Expression Profiling
Goats
/ genetics
Hair Follicle
/ physiology
Keratins
/ genetics
Molecular Sequence Annotation
Oncostatin M
/ metabolism
Receptors, G-Protein-Coupled
/ genetics
Textiles
Transcriptome
Wnt Signaling Pathway
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 04 2020
08 04 2020
Historique:
received:
09
12
2019
accepted:
19
03
2020
entrez:
10
4
2020
pubmed:
10
4
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Pashmina, the world's finest natural fiber is derived from secondary hair follicles of Changthangi goats which are domesticated in Ladakh region of Jammu and Kashmir by nomadic pastoralists. Complex epithelial-mesenchymal interactions involving numerous signal molecules and signaling pathways govern hair follicle morphogenesis and mitosis across different species. The present study involved transcriptome profiling of skin from fiber type Changthangi goats and meat type Barbari goats to unravel gene networks and metabolic pathways that might contribute to Pashmina development. In Changthangi goats, 525 genes were expressed at significantly higher levels and 54 at significantly lower levels with fold change >2 (p
Identifiants
pubmed: 32269277
doi: 10.1038/s41598-020-63023-6
pii: 10.1038/s41598-020-63023-6
pmc: PMC7142143
doi:
Substances chimiques
Cornified Envelope Proline-Rich Proteins
0
GPRC5D protein, human
0
Receptors, G-Protein-Coupled
0
Oncostatin M
106956-32-5
Keratins
68238-35-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6050Références
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