Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription.
adrenocorticotropic hormone
corticotroph
glucocorticoids
hypothalamic–pituitary–adrenal axis
nuclear receptor
pro-opiomelanocortin
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
07 04 2020
07 04 2020
Historique:
received:
22
02
2020
revised:
29
03
2020
accepted:
01
04
2020
entrez:
11
4
2020
pubmed:
11
4
2020
medline:
13
3
2021
Statut:
epublish
Résumé
The hypothalamic-pituitary-adrenal (HPA) axis plays a critical role in adaptive stress responses and maintaining organism homeostasis. The pituitary corticotroph is the central player in the HPA axis and is regulated by a plethora of hormonal and stress related factors that synergistically interact to activate and temper pro-opiomelanocortin (POMC) transcription, to either increase or decrease adrenocorticotropic hormone (ACTH) production and secretion as needed. Nuclear receptors are a family of highly conserved transcription factors that can also be induced by various physiologic signals, and they mediate their responses via multiple targets to regulate metabolism and homeostasis. In this review, we summarize the modulatory roles of nuclear receptors on pituitary corticotroph cell POMC transcription, describe the unique and complex role these factors play in hypothalamic-pituitary-adrenal axis (HPA) regulation and discuss potential therapeutic targets in disease states.
Identifiants
pubmed: 32272677
pii: cells9040900
doi: 10.3390/cells9040900
pmc: PMC7226830
pii:
doi:
Substances chimiques
Receptors, Cytoplasmic and Nuclear
0
Transcription Factors
0
Pro-Opiomelanocortin
66796-54-1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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