Long-term Metabolic and Socioeducational Outcomes of Transient Neonatal Diabetes: A Longitudinal and Cross-sectional Study.
Adolescent
Adult
Case-Control Studies
Child
Cross-Sectional Studies
Diabetes Mellitus
/ congenital
Educational Status
Female
Glucose Clamp Technique
Humans
Infant, Newborn
Infant, Newborn, Diseases
/ diagnosis
Insulin Resistance
/ physiology
Insulin Secretion
/ physiology
Longitudinal Studies
Male
Prognosis
Socioeconomic Factors
Young Adult
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
15
02
2019
accepted:
05
03
2020
pubmed:
11
4
2020
medline:
5
3
2021
entrez:
11
4
2020
Statut:
ppublish
Résumé
Transient neonatal diabetes mellitus (TNDM) occurs during the 1st year of life and remits during childhood. We investigated glucose metabolism and socioeducational outcomes in adults. We included 27 participants with a history of TNDM currently with ( In TNDM participants, age at relapse correlated positively with age at puberty ( Relapse of diabetes occurred earlier in TNDM participants compared with relatives and was associated with puberty. Both groups had decreased educational attainment, and those with diabetes had lower insulin secretion capacity; however, there was no difference in insulin resistance in adulthood. These forms of diabetes should be included in maturity-onset diabetes of the young testing panels, and relatives of TNDM patients should be screened for underlying defects, as they may be treated with drugs other than insulin.
Identifiants
pubmed: 32273272
pii: dc19-0324
doi: 10.2337/dc19-0324
doi:
Banques de données
ClinicalTrials.gov
['NCT02072551']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1191-1199Investigateurs
Sawsan Abu-Amara Olivieri
(S)
Nadège Bachere
(N)
Christine Bellanne-Chantelot
(C)
Anne-Marie Bertrand
(AM)
Olivier Bourron
(O)
Fabienne De Boisvilliers
(F)
Bernard Deumier
(B)
Pierre Gourdy
(P)
Agnès Hartemann
(A)
Stephanie Jellimann
(S)
Claire Le Tallec
(C)
Amélie Martin-Dessilla
(A)
Anne Paoli
(A)
Mireille Perrin
(M)
Jean Ribstein
(J)
Cécile Saint-Martin
(C)
Charles Thivolet
(C)
Bernard Vialettes
(B)
Hubert Ythier
(H)
Informations de copyright
© 2020 by the American Diabetes Association.