Machine learning highlights the deficiency of conventional dosimetric constraints for prevention of high-grade radiation esophagitis in non-small cell lung cancer treated with chemoradiation.

Chemoradiation Intensity-modulated radiation therapy Machine learning Non-small cell lung cancer Proton beam therapy Radiation esophagitis Radiation-induced toxicity

Journal

Clinical and translational radiation oncology
ISSN: 2405-6308
Titre abrégé: Clin Transl Radiat Oncol
Pays: Ireland
ID NLM: 101713416

Informations de publication

Date de publication:
May 2020
Historique:
received: 16 12 2019
revised: 17 03 2020
accepted: 21 03 2020
entrez: 11 4 2020
pubmed: 11 4 2020
medline: 11 4 2020
Statut: epublish

Résumé

Radiation esophagitis is a clinically important toxicity seen with treatment for locally-advanced non-small cell lung cancer. There is considerable disagreement among prior studies in identifying predictors of radiation esophagitis. We apply machine learning algorithms to identify factors contributing to the development of radiation esophagitis to uncover previously unidentified criteria and more robust dosimetric factors. We used machine learning approaches to identify predictors of grade ≥ 3 radiation esophagitis in a cohort of 202 consecutive locally-advanced non-small cell lung cancer patients treated with definitive chemoradiation from 2008 to 2016. We evaluated 35 clinical features per patient grouped into risk factors, comorbidities, imaging, stage, histology, radiotherapy, chemotherapy and dosimetry. Univariate and multivariate analyses were performed using a panel of 11 machine learning algorithms combined with predictive power assessments. All patients were treated to a median dose of 66.6 Gy at 1.8 Gy per fraction using photon (89.6%) and proton (10.4%) beam therapy, most often with concurrent chemotherapy (86.6%). 11.4% of patients developed grade ≥ 3 radiation esophagitis. On univariate analysis, no individual feature was found to predict radiation esophagitis (AUC range 0.45-0.55, p ≥ 0.07). In multivariate analysis, all machine learning algorithms exhibited poor predictive performance (AUC range 0.46-0.56, p ≥ 0.07). Contemporary machine learning algorithms applied to our modern, relatively large institutional cohort could not identify any reliable predictors of grade ≥ 3 radiation esophagitis. Additional patients are needed, and novel patient-specific and treatment characteristics should be investigated to develop clinically meaningful methods to mitigate this survival altering toxicity.

Sections du résumé

BACKGROUND AND PURPOSE OBJECTIVE
Radiation esophagitis is a clinically important toxicity seen with treatment for locally-advanced non-small cell lung cancer. There is considerable disagreement among prior studies in identifying predictors of radiation esophagitis. We apply machine learning algorithms to identify factors contributing to the development of radiation esophagitis to uncover previously unidentified criteria and more robust dosimetric factors.
MATERIALS AND METHODS METHODS
We used machine learning approaches to identify predictors of grade ≥ 3 radiation esophagitis in a cohort of 202 consecutive locally-advanced non-small cell lung cancer patients treated with definitive chemoradiation from 2008 to 2016. We evaluated 35 clinical features per patient grouped into risk factors, comorbidities, imaging, stage, histology, radiotherapy, chemotherapy and dosimetry. Univariate and multivariate analyses were performed using a panel of 11 machine learning algorithms combined with predictive power assessments.
RESULTS RESULTS
All patients were treated to a median dose of 66.6 Gy at 1.8 Gy per fraction using photon (89.6%) and proton (10.4%) beam therapy, most often with concurrent chemotherapy (86.6%). 11.4% of patients developed grade ≥ 3 radiation esophagitis. On univariate analysis, no individual feature was found to predict radiation esophagitis (AUC range 0.45-0.55, p ≥ 0.07). In multivariate analysis, all machine learning algorithms exhibited poor predictive performance (AUC range 0.46-0.56, p ≥ 0.07).
CONCLUSIONS CONCLUSIONS
Contemporary machine learning algorithms applied to our modern, relatively large institutional cohort could not identify any reliable predictors of grade ≥ 3 radiation esophagitis. Additional patients are needed, and novel patient-specific and treatment characteristics should be investigated to develop clinically meaningful methods to mitigate this survival altering toxicity.

Identifiants

pubmed: 32274426
doi: 10.1016/j.ctro.2020.03.007
pii: S2405-6308(20)30020-3
pmc: PMC7132156
doi:

Types de publication

Journal Article

Langues

eng

Pagination

69-75

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2020 The Author(s).

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Auteurs

José Marcio Luna (JM)

Department of Radiation Oncology, University of Pennsylvania, Perelman Center for Advanced Medicine, 3400 Civic Center Blvd, Philadelphia, PA 19104, United States.

Hann-Hsiang Chao (HH)

Department of Radiation Oncology, Hunter Holmes McGuire Veterans Affairs Medical Center, 1201 Broad Rock Blvd, Richmond, VA 23249, United States.

Russel T Shinohara (RT)

Department of Biostatistics and Epidemiology, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA 19104, United States.

Lyle H Ungar (LH)

Department of Computer and Information Science, University of Pennsylvania, 3330 Walnut St, Philadelphia, PA 19104, United States.

Keith A Cengel (KA)

Department of Radiation Oncology, University of Pennsylvania, Perelman Center for Advanced Medicine, 3400 Civic Center Blvd, Philadelphia, PA 19104, United States.

Daniel A Pryma (DA)

Department of Radiology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, United States.

Chidambaram Chinniah (C)

Albany Medical College, 43 New Scotland Ave, Albany, NY 12208, United States.

Abigail T Berman (AT)

Department of Radiation Oncology, University of Pennsylvania, Perelman Center for Advanced Medicine, 3400 Civic Center Blvd, Philadelphia, PA 19104, United States.

Sharyn I Katz (SI)

Department of Radiology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, United States.

Despina Kontos (D)

Department of Radiology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, United States.

Charles B Simone (CB)

Department of Radiation Oncology, New York Proton Center, 225 East 126 St, New York, NY 10035, United States.

Eric S Diffenderfer (ES)

Department of Radiation Oncology, University of Pennsylvania, Perelman Center for Advanced Medicine, 3400 Civic Center Blvd, Philadelphia, PA 19104, United States.

Classifications MeSH