A Photoswitchable Inhibitor of the Human Serotonin Transporter.
Photopharmacology
neurotransmitter
photochromic ligand
serotonin
transporter
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
06 05 2020
06 05 2020
Historique:
pubmed:
11
4
2020
medline:
22
6
2021
entrez:
11
4
2020
Statut:
ppublish
Résumé
The human serotonin transporter (hSERT) terminates serotonergic signaling through reuptake of neurotransmitter into presynaptic neurons and is a target for many antidepressant drugs. We describe here the development of a photoswitchable hSERT inhibitor, termed azo-escitalopram, that can be reversibly switched between
Identifiants
pubmed: 32275382
doi: 10.1021/acschemneuro.9b00521
pmc: PMC8022892
mid: NIHMS1681391
doi:
Substances chimiques
Antidepressive Agents
0
SLC6A4 protein, human
0
Serotonin Plasma Membrane Transport Proteins
0
Serotonin Uptake Inhibitors
0
Citalopram
0DHU5B8D6V
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1231-1237Subventions
Organisme : NINDS NIH HHS
ID : R01 NS108151
Pays : United States
Références
J Biol Chem. 2012 Nov 16;287(47):39316-26
pubmed: 23007398
ACS Chem Neurosci. 2015 May 20;6(5):701-7
pubmed: 25741856
J Neurochem. 2005 Jan;92(1):21-8
pubmed: 15606893
Nat Commun. 2015 May 22;6:7118
pubmed: 25997690
ACS Chem Neurosci. 2017 Aug 16;8(8):1668-1672
pubmed: 28414419
ACS Cent Sci. 2019 Apr 24;5(4):607-618
pubmed: 31041380
Nat Chem Biol. 2016 Sep;12(9):755-62
pubmed: 27454932
ACS Chem Neurosci. 2013 Jan 16;4(1):5-8
pubmed: 23336036
Chem Soc Rev. 2011 Aug;40(8):4422-37
pubmed: 21483974
Angew Chem Int Ed Engl. 2014 Mar 17;53(12):3264-7
pubmed: 24519993
J Med Chem. 2010 Aug 26;53(16):6112-21
pubmed: 20672825
Bioorg Med Chem. 2016 Jun 15;24(12):2725-38
pubmed: 27160055
Eur Neuropsychopharmacol. 2005 Mar;15(2):193-8
pubmed: 15695064
Pharmacol Rep. 2013;65(4):771-86
pubmed: 24145072
Angew Chem Int Ed Engl. 2014 Jul 14;53(29):7657-60
pubmed: 24895330
Nature. 2016 Apr 21;532(7599):334-9
pubmed: 27049939
Psychopharmacology (Berl). 2012 Jan;219(1):1-13
pubmed: 21901317
Org Lett. 2009 Dec 17;11(24):5598-601
pubmed: 19911824
J Med Chem. 2014 Aug 14;57(15):6809-21
pubmed: 25025595
Angew Chem Int Ed Engl. 2010 Sep 24;49(40):7234-8
pubmed: 20803592
Neuropharmacology. 2019 Dec 15;161:107548
pubmed: 30807752
Chem Rev. 2018 Nov 14;118(21):10710-10747
pubmed: 29985590
Chem Rev. 2008 May;108(5):1614-41
pubmed: 18476671
Int Clin Psychopharmacol. 1994 Mar;9 Suppl 1:19-26
pubmed: 8021435
Curr Opin Chem Biol. 2019 Jun;50:145-151
pubmed: 31108317
J Am Chem Soc. 2010 Feb 3;132(4):1311-22
pubmed: 20055463
Bioorg Med Chem Lett. 2013 Jan 1;23(1):323-6
pubmed: 23168018
Nat Rev Neurosci. 2008 Feb;9(2):85-96
pubmed: 18209729
Chem Sci. 2019 Nov 19;11(2):429-434
pubmed: 32190263
Nat Chem. 2015 Jul;7(7):554-561
pubmed: 26100803
Acc Chem Res. 2015 Jul 21;48(7):1947-60
pubmed: 26103428
Angew Chem Int Ed Engl. 2016 Sep 5;55(37):10978-99
pubmed: 27376241
Angew Chem Int Ed Engl. 2012 Jun 4;51(23):5748-51
pubmed: 22517577
Annu Rev Med. 2009;60:355-66
pubmed: 19630576
J Med Chem. 2018 Mar 22;61(6):2133-2165
pubmed: 28731336
Nat Neurosci. 2013 Apr;16(4):507-16
pubmed: 23455609
J Biol Chem. 2010 Jan 15;285(3):2051-63
pubmed: 19892699
Nat Chem Biol. 2019 Jun;15(6):623-631
pubmed: 31036923