Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus.
RSV
benzimidazole
fusion inhibitor
machine learning
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
08 05 2020
08 05 2020
Historique:
pubmed:
11
4
2020
medline:
3
6
2021
entrez:
11
4
2020
Statut:
ppublish
Résumé
A series of five benzimidazole-based compounds were identified using a machine learning algorithm as potential inhibitors of the respiratory syncytial virus (RSV) fusion protein. These compounds were synthesized, and compound
Identifiants
pubmed: 32275393
doi: 10.1021/acsinfecdis.9b00524
pmc: PMC7456560
mid: NIHMS1614500
doi:
Substances chimiques
Antiviral Agents
0
Benzimidazoles
0
Viral Fusion Proteins
0
benzimidazole
E24GX49LD8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
922-929Subventions
Organisme : NIAID NIH HHS
ID : R01 AI071002
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI153400
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD079327
Pays : United States
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