Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice.

Acinar Cells / metabolism Animals Carcinoma, Pancreatic Ductal / genetics Cell Transformation, Neoplastic / genetics Genes, ras / genetics Male Mice Mice, Inbred C57BL Mice, Transgenic Pancreas / metabolism Pancreatic Neoplasms / genetics Precancerous Conditions / genetics Proto-Oncogene Proteins c-vav / genetics Proto-Oncogene Proteins p21(ras) / genetics Signal Transduction / genetics Pancreatic Neoplasms

Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
05 2020
Historique:
received: 28 01 2020
revised: 20 03 2020
accepted: 23 03 2020
entrez: 12 4 2020
pubmed: 12 4 2020
medline: 3 6 2021
Statut: epublish

Résumé

To explore the contribution of Vav1, a hematopoietic signal transducer, to pancreatic ductal adenocarcinoma (PDAC) development, we generated transgenic mouse lines expressing, Vav1, K-Ras

Identifiants

DOI: 10.26508/lsa.202000661 PMID: 32277014 PMC: PMC7156281
pubmed: 32277014
pii: 3/5/e202000661
doi: 10.26508/lsa.202000661
pmc: PMC7156281
pii:
doi:

Substances chimiques

Proto-Oncogene Proteins c-vav 0
VAV1 protein, human 0
Vav1 protein, mouse 0
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2020 Salaymeh et al.

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Auteurs

Yaser Salaymeh (Y)

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel.

Marganit Farago (M)

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel.

Shulamit Sebban (S)

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel.

Batel Shalom (B)

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel.

Eli Pikarsky (E)

The Lautenberg Center for Immunology and Cancer Research and Department of Pathology, Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel.

Shulamit Katzav (S)

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel shulamitk@ekmd.huji.ac.il.
ORCID: 0000-0002-6878-2139

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules acineuses › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › Eucaryotes › Animaux › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Oncogènes › Proto-oncogènes › Gènes ras › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › Système digestif › Pancréas › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › Tumeurs › États précancéreux › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-vav › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Vav1 and mutant K-Ras synergize in the early...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Vav1 and mutant K-Ras synergize in the early...