Beyond 10 years, with or without an intestinal graft: Present and future?
clinical research/practice
complication
intestinal (allograft) function/dysfunction
intestine/multivisceral transplantation
pathology/histopathology
pediatrics
quality of life (QOL)
rejection
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
19
09
2019
revised:
12
03
2020
accepted:
18
03
2020
pubmed:
12
4
2020
medline:
22
6
2021
entrez:
12
4
2020
Statut:
ppublish
Résumé
Long-term outcomes in children undergoing intestinal transplantation remain unclear. Seventy-one children underwent intestinal transplantation in our center from 1989 to 2007. We report on 10-year posttransplant outcomes with (group 1, n = 26) and without (group 2, n = 9) a functional graft. Ten-year patient and graft survival rates were 53% and 36%, respectively. Most patients were studying or working, one third having psychiatric disorders. All patients in group 1 were weaned off parenteral nutrition with mostly normal physical growth and subnormal energy absorption. Graft histology from 15 late biopsies showed minimal abnormality. However, micronutrient deficiencies and fat malabsorption were frequent; biliary complications occurred in 4 patients among the 17 who underwent liver transplantation; median renal clearance was 87 mL/min/1.73 m
Identifiants
pubmed: 32277553
doi: 10.1111/ajt.15899
pii: S1600-6135(22)22468-X
doi:
Substances chimiques
Immunosuppressive Agents
0
Mycophenolic Acid
HU9DX48N0T
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2802-2812Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.
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