Oligodendrogenesis and Myelin Formation in the Forebrain Require Platelet-derived Growth Factor Receptor-alpha.

Animals Cell Differentiation Mice Myelin Sheath / metabolism Oligodendroglia / metabolism Prosencephalon / metabolism Receptor, Platelet-Derived Growth Factor alpha / genetics
PDGFRα differentiation hypomyelination oligodendrocytes survival vascular abnormality

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
01 06 2020
Historique:
received: 29 06 2019
revised: 19 03 2020
accepted: 01 04 2020
pubmed: 13 4 2020
medline: 15 5 2021
entrez: 13 4 2020
Statut: ppublish

Résumé

The platelet-derived growth factor receptor-α (PDGFRα) principally mediates growth factor signals in oligodendroglial progenitors and is involved in oligodendrogenesis and myelinogenesis in the developing spinal cord. However, the role of PDGFRα in the developing forebrain remains relatively unknown. We established a conditional knockout mouse for the Pdgfra gene (N-PRα-KO) using a Nestin promoter/enhancer-driven Cre recombinase and examined forebrain development. The expression of PDGFRα was efficiently suppressed in the Olig2

Identifiants

DOI: 10.1016/j.neuroscience.2020.04.001 PMID: 32278722
pubmed: 32278722
pii: S0306-4522(20)30216-5
doi: 10.1016/j.neuroscience.2020.04.001
pii:
doi:

Substances chimiques

Receptor, Platelet-Derived Growth Factor alpha EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11-26

Informations de copyright

Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

Auteurs

Takeru Hamashima (T)

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

Yoko Ishii (Y)

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan; Department of Health Science, Faculty of Health and Human Development, The University of Nagano, Nagano 380-8525, Japan.

Linh Quang Nguyen (LQ)

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

Noriko Okuno (N)

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

Yang Sang (Y)

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

Takako Matsushima (T)

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

Yoichi Kurashige (Y)

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

Hirohide Takebayashi (H)

Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan.

Hisashi Mori (H)

Department of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

Toshihiko Fujimori (T)

Division of Embryology, National Institute for Basic Biology, Okazaki 444-8787, Japan.

Seiji Yamamoto (S)

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan. Electronic address: seiyama@med.u-toyama.ac.jp.

Masakiyo Sasahara (M)

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan. Electronic address: sasahara@med.u-toyama.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Oligodendrogenesis and Myelin Formation in the...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Oligodendrogenesis and Myelin Formation in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Oligodendrogenesis and Myelin Formation in the...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Gaine de myéline › Oligodendrogenesis and Myelin Formation in the...
questionsmedicales.fr › Cellules › Névroglie › Oligodendroglie › Oligodendrogenesis and Myelin Formation in the...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Oligodendrogenesis and Myelin Formation in the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs aux facteurs de croissance dérivés des plaquettes › Récepteur au PDGF alpha › Oligodendrogenesis and Myelin Formation in the...