Tibolone, alendronate, and simvastatin enhance implant osseointegration in a preclinical in vivo model.
animal experiments
bone regeneration
bone-implant interactions
drug delivery
guided tissue regeneration
pharmacology
Journal
Clinical oral implants research
ISSN: 1600-0501
Titre abrégé: Clin Oral Implants Res
Pays: Denmark
ID NLM: 9105713
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
17
04
2019
revised:
13
02
2020
accepted:
31
03
2020
pubmed:
13
4
2020
medline:
3
7
2020
entrez:
13
4
2020
Statut:
ppublish
Résumé
The objective of the study was to evaluate and compare the effect of different drugs such as simvastatin, alendronate, and tibolone for titanium implant osseointegration enhancement. Eighty female albino Wistar rats were equally divided into five groups: Group I (ovariectomy), Group II (sham ovariectomy), Group III (alendronate + ovariectomy), Group IV (simvastatin + ovariectomy), and Group V (tibolone + ovariectomy). Three months after ovariectomy, we performed bilateral titanium intramedullary nailing in all groups, followed by oral administration of alendronate, simvastatin, or tibolone for 12 weeks. Examinations included micro-CT, mechanical pull-out test, histology, and bone serum markers. Peri-implant micro-CT analysis showed a significantly higher overall bone tissue in tibolone compared to the ovariectomy group, while no significant difference was found between the treatment groups. Sham ovariectomy, alendronate, and tibolone groups had a higher body mass density compared to ovariectomy and simvastatin groups. All treatment groups had a greater thickness of the peri-implant compact bone layer compared to ovariectomy group, but the results were not statistically significant. Tibolone presented the highest values in pull-out test, but alendronate showed more consistently positive results compared to other groups. Osteocalcin had in the tibolone group almost three times the value in the ovariectomy group, but the results were not statistically significant. The hypothesis that alendronate, simvastatin, and tibolone enhance the osseointegration process of intramedullary titanium implants in ovariectomized rats has been accepted, while tibolone could offer the best results.
Substances chimiques
Dental Implants
0
Norpregnenes
0
Simvastatin
AGG2FN16EV
Titanium
D1JT611TNE
tibolone
FF9X0205V2
Alendronate
X1J18R4W8P
Types de publication
Journal Article
Langues
eng
Pagination
655-668Subventions
Organisme : Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca
ID : 1680/19.01.2018
Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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