A trial of lacosamide for benign convulsions with gastroenteritis.
Benign convulsions with gastroenteritis
Efficacy
Lacosamide
Tolerability
Journal
Brain & development
ISSN: 1872-7131
Titre abrégé: Brain Dev
Pays: Netherlands
ID NLM: 7909235
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
06
02
2020
revised:
05
03
2020
accepted:
25
03
2020
pubmed:
14
4
2020
medline:
9
3
2021
entrez:
14
4
2020
Statut:
ppublish
Résumé
Benign convulsions with gastroenteritis are characterized by a cluster of seizures. Sodium channel blockers are efficacious. We prescribed lacosamide, a new channel blocker, for five patients. Patient age ranged from 17 to 33 months; all five experienced 1-4 generalized convulsions persisting for 30-120 s. One patient exhibited a transient splenial lesion on head magnetic resonance imaging. All received one dose (2 mg/kg) of lacosamide. The convulsions ceased, and no adverse drug effect was noted. A single dose of lacosamide was effective and well-tolerated in five patients with benign convulsions with gastroenteritis.
Identifiants
pubmed: 32279898
pii: S0387-7604(20)30115-7
doi: 10.1016/j.braindev.2020.03.006
pii:
doi:
Substances chimiques
Voltage-Gated Sodium Channel Blockers
0
Lacosamide
563KS2PQY5
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
551-554Informations de copyright
Copyright © 2020 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.