The secreted protein DEL-1 activates a β3 integrin-FAK-ERK1/2-RUNX2 pathway and promotes osteogenic differentiation and bone regeneration.

Animals Bone Regeneration Calcium-Binding Proteins / genetics Cell Adhesion Molecules / genetics Cell Differentiation Core Binding Factor Alpha 1 Subunit / genetics Focal Adhesion Kinase 1 / genetics Integrin beta3 / genetics MAP Kinase Signaling System Mice Mice, Knockout Mitogen-Activated Protein Kinase 1 / genetics Mitogen-Activated Protein Kinase 3 / genetics Osteoblasts / cytology Osteogenesis
bone bone loss bone regeneration developmental endothelial locus-1 (DEL-1) extracellular matrix inflammation integrin osteoblast osteogenesis periodontal disease periodontitis

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
22 05 2020
Historique:
received: 13 02 2020
revised: 08 04 2020
pubmed: 14 4 2020
medline: 29 12 2020
entrez: 14 4 2020
Statut: ppublish

Résumé

The integrin-binding secreted protein developmental endothelial locus-1 (DEL-1) is involved in the regulation of both the initiation and resolution of inflammation in different diseases, including periodontitis, an oral disorder characterized by inflammatory bone loss. Here, using a mouse model of bone regeneration and

Identifiants

DOI: 10.1074/jbc.RA120.013024 PMID: 32280065 PMC: PMC7247308
pubmed: 32280065
pii: S0021-9258(17)50261-6
doi: 10.1074/jbc.RA120.013024
pmc: PMC7247308
pii:
doi:

Substances chimiques

Calcium-Binding Proteins 0
Cell Adhesion Molecules 0
Core Binding Factor Alpha 1 Subunit 0
Edil3 protein, mouse 0
Integrin beta3 0
Runx2 protein, mouse 0
Focal Adhesion Kinase 1 EC 2.7.10.2
Ptk2 protein, mouse EC 2.7.10.2
Mapk1 protein, mouse EC 2.7.11.24
Mapk3 protein, mouse EC 2.7.11.24
Mitogen-Activated Protein Kinase 1 EC 2.7.11.24
Mitogen-Activated Protein Kinase 3 EC 2.7.11.24

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7261-7273

Subventions

Organisme : NIDCR NIH HHS
ID : R01 DE024716
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028561
Pays : United States
Organisme : NIDCR NIH HHS
ID : R37 DE026152
Pays : United States

Informations de copyright

© 2020 Yuh et al.

Références

J Dent Res. 2014 Nov;93(11):1045-53
pubmed: 25261053
J Bone Miner Res. 1992 Jun;7(6):683-92
pubmed: 1414487
Arthritis Rheum. 2012 May;64(5):1540-50
pubmed: 22139865
Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18587-91
pubmed: 19843692
Thromb Haemost. 2014 May 5;111(5):1004-6
pubmed: 24352615
Cell Host Microbe. 2013 May 15;13(5):595-601
pubmed: 23684310
Sci Transl Med. 2018 Oct 17;10(463):
pubmed: 30333238
Periodontol 2000. 2015 Jun;68(1):182-216
pubmed: 25867987
J Immunol. 2004 Mar 15;172(6):3876-82
pubmed: 15004195
ASGSB Bull. 1995 Oct;8(2):19-28
pubmed: 11538547
Eur Cell Mater. 2012 Jul 09;24:1-17
pubmed: 22777949
J Cell Physiol. 2011 Nov;226(11):3043-52
pubmed: 21302301
Trends Immunol. 2013 Jan;34(1):1-6
pubmed: 22951309
Thromb Haemost. 2009 Aug;102(2):191-7
pubmed: 19652868
Mol Psychiatry. 2015 Jul;20(7):880-888
pubmed: 25385367
EMBO Mol Med. 2013 May;5(5):661-74
pubmed: 23592557
Differentiation. 2009 Sep-Oct;78(2-3):79-90
pubmed: 19433344
Differentiation. 2012 Sep;84(2):185-92
pubmed: 22664173
J Clin Invest. 2017 Oct 2;127(10):3624-3639
pubmed: 28846069
J Cell Physiol. 2007 Jun;211(3):661-72
pubmed: 17348033
J Bone Miner Res. 2002 Jan;17(1):15-25
pubmed: 11771662
Cell. 2013 May 9;153(4):910-8
pubmed: 23643243
Trends Endocrinol Metab. 2014 Nov;25(11):567-75
pubmed: 25034128
PLoS One. 2017 Nov 28;12(11):e0188749
pubmed: 29182679
Biomaterials. 2010 Apr;31(12):3244-52
pubmed: 20149448
J Bone Miner Res. 2012 Mar;27(3):538-51
pubmed: 22072425
Am J Pathol. 2014 Feb;184(2):472-82
pubmed: 24269593
Virulence. 2015;6(3):229-35
pubmed: 25574929
Nat Immunol. 2019 Jan;20(1):40-49
pubmed: 30455459
Sci Transl Med. 2017 Dec 13;9(420):
pubmed: 29237758
Trends Mol Med. 2019 May;25(5):444-459
pubmed: 30885428
J Immunol Methods. 2013 Aug 30;394(1-2):49-54
pubmed: 23672778
Nat Commun. 2015 Sep 16;6:8272
pubmed: 26374165
J Cell Biol. 2000 Oct 30;151(3):483-94
pubmed: 11062251
Int J Radiat Oncol Biol Phys. 2006 Aug 1;65(5):1536-43
pubmed: 16863930
Bone. 1999 Jul;25(1):95-6
pubmed: 10423030
Sci Transl Med. 2015 Sep 30;7(307):307ra155
pubmed: 26424570
J Periodontal Res. 1966;1(3):193-204
pubmed: 4225530
Mol Cell Endocrinol. 2015 Sep 15;413:78-89
pubmed: 26116229
J Biol Chem. 2015 Mar 13;290(11):6903-12
pubmed: 25631051
Mol Cancer Ther. 2009 Mar;8(3):543-51
pubmed: 19258428
Nat Immunol. 2012 Mar 25;13(5):465-73
pubmed: 22447028
Bone. 2015 Feb;71:244-56
pubmed: 25460184
Genome Biol. 2014 Mar 21;15(3):R52
pubmed: 24655370
Science. 2008 Nov 14;322(5904):1101-4
pubmed: 19008446
Cell Tissue Res. 2007 Oct;330(1):83-95
pubmed: 17701220
J Periodontol. 2015 May;86(5):611-22
pubmed: 25688694
Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18525-30
pubmed: 24167272
Nat Rev Endocrinol. 2013 May;9(5):288-95
pubmed: 23358353
Nat Rev Immunol. 2015 Jan;15(1):30-44
pubmed: 25534621
Nat Commun. 2018 Feb 16;9(1):701
pubmed: 29453398
Dev Growth Differ. 2014 Jan;56(1):122-9
pubmed: 24372541
FASEB J. 2012 Apr;26(4):1423-30
pubmed: 22179526
J Dent Res. 2015 Jan;94(1):148-56
pubmed: 25389003
Cancer Res. 2002 Aug 1;62(15):4263-72
pubmed: 12154028
J Biol Chem. 2013 Jul 12;288(28):20488-98
pubmed: 23720781
Cold Spring Harb Protoc. 2016 Feb 01;2016(2):pdb.prot090704
pubmed: 26832688
J Proteomics. 2015 Feb 26;116:81-96
pubmed: 25585129
J Clin Periodontol. 2008 Feb;35(2):89-105
pubmed: 18199146
Nat Protoc. 2013 Nov;8(11):2281-2308
pubmed: 24157548
Nat Rev Drug Discov. 2010 Oct;9(10):804-20
pubmed: 20885411
Mol Cell Endocrinol. 2004 Dec 30;228(1-2):79-102
pubmed: 15541574
J Cell Biol. 2004 Jul 5;166(1):85-95
pubmed: 15226309
J Periodontol. 2015 Feb;86(2 Suppl):S134-52
pubmed: 25644297
Science. 2013 Feb 15;339(6121):819-23
pubmed: 23287718
Arkh Patol. 1996 Jan-Feb;58(1):66-7
pubmed: 8929146
Stem Cell Res. 2015 Nov;15(3):618-628
pubmed: 26513557
Int J Biochem Cell Biol. 1997 Aug-Sep;29(8-9):1085-96
pubmed: 9416004
Genes Dev. 1998 Jan 1;12(1):21-33
pubmed: 9420328
Eur J Oral Sci. 2017 Aug;125(4):258-264
pubmed: 28643381
J Immunol. 2016 Oct 1;197(7):2796-806
pubmed: 27543615
Exp Cell Res. 2010 Aug 15;316(14):2291-300
pubmed: 20483354
Periodontol 2000. 2011 Feb;55(1):87-103
pubmed: 21134230

Auteurs

Da-Yo Yuh (DY)

Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

Tomoki Maekawa (T)

Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8514, Japan.

Xiaofei Li (X)

Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

Tetsuhiro Kajikawa (T)

Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

Khalil Bdeir (K)

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

Triantafyllos Chavakis (T)

Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Technische Universität Dresden, 001069 Dresden, Germany.

George Hajishengallis (G)

Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104. Electronic address: geoh@upenn.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Remodelage osseux › Régénération osseuse › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription CBF › Sous-unités alpha du facteur CBF › Sous-unité alpha 1 du facteur CBF › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Focal adhesion kinase 1 › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Intégrines › Chaines bêta des intégrines › Intégrine bêta3 › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Extracellular Signal-Regulated MAP Kinases › Mitogen-Activated Protein Kinase 1 › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Extracellular Signal-Regulated MAP Kinases › Mitogen-Activated Protein Kinase 3 › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › The secreted protein DEL-1 activates a β3...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › The secreted protein DEL-1 activates a β3...