Fastidious chemical decontamination after cyclophosphamide vial breakage in a compounding unit.
Antineoplastic drugs
chemical incidents
risk assessment
Journal
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
ISSN: 1477-092X
Titre abrégé: J Oncol Pharm Pract
Pays: England
ID NLM: 9511372
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
pubmed:
14
4
2020
medline:
8
1
2021
entrez:
14
4
2020
Statut:
ppublish
Résumé
An important amount of cytotoxic drug may accumulate in the workplace following the breakage of a vial containing an anticancer drug. Thanks to the monthly monitoring of the surface contamination in our compounding unit, a strong increase of cyclophosphamide contamination was highlighted in the storage area following the breakage of the vial, despite application of the emergency procedure. This study presents an analysis of chemical decontamination in the context of massive contamination. Samples were taken on the floor and on the caster of a storage shelf where the vial broke. The residual contamination was measured with a liquid chromatography-mass spectrometry/mass spectrometry method. An admixture of 10
Identifiants
pubmed: 32281518
doi: 10.1177/1078155220915961
doi:
Substances chimiques
Antineoplastic Agents, Alkylating
0
Cyclophosphamide
8N3DW7272P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM