Cord blood-derived platelet concentrates as starting material for new therapeutic blood components prepared in a public cord blood bank: from product development to clinical application.
Journal
Blood transfusion = Trasfusione del sangue
ISSN: 2385-2070
Titre abrégé: Blood Transfus
Pays: Italy
ID NLM: 101237479
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
04
12
2019
accepted:
25
02
2020
pubmed:
14
4
2020
medline:
22
1
2021
entrez:
14
4
2020
Statut:
ppublish
Résumé
There are many advantages to using cord blood (CB) as a source of therapeutic platelet and plasma derivatives for regenerative medicine. These include availability, universal use, young donor source, and virally safe biological material, rich in tissue regenerative factors. We aimed to validate a bioprocess design for the production of cord blood-derived platelet concentrates (CBPC) in a public Cord Blood Bank (CBB). CBPC was defined as a product of 10±5 mL, 1,000±200×10 After processing, 84% of the products fulfilled the acceptance criteria. Final products contained 1,017±149×10 We designed and validated a highly reproducible, closed system method to manufacture high quality CBPC suitable for clinical applications using CB units not suitable for transplantation in a public CBB.
Sections du résumé
BACKGROUND
There are many advantages to using cord blood (CB) as a source of therapeutic platelet and plasma derivatives for regenerative medicine. These include availability, universal use, young donor source, and virally safe biological material, rich in tissue regenerative factors.
MATERIALS AND METHODS
We aimed to validate a bioprocess design for the production of cord blood-derived platelet concentrates (CBPC) in a public Cord Blood Bank (CBB). CBPC was defined as a product of 10±5 mL, 1,000±200×10
RESULTS
After processing, 84% of the products fulfilled the acceptance criteria. Final products contained 1,017±149×10
DISCUSSION
We designed and validated a highly reproducible, closed system method to manufacture high quality CBPC suitable for clinical applications using CB units not suitable for transplantation in a public CBB.
Identifiants
pubmed: 32281925
pii: 2020.0305-19
doi: 10.2450/2020.0305-19
pmc: PMC7250694
doi:
Substances chimiques
Platelet-Derived Growth Factor
0
TGFB1 protein, human
0
Transforming Growth Factor beta1
0
platelet-derived growth factor AB
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
208-216Références
Bull Exp Biol Med. 2017 Feb;162(4):528-533
pubmed: 28243902
Transfusion. 2017 Apr;57(4):1058-1065
pubmed: 28182293
Transfus Apher Sci. 2017 Aug;56(4):595-604
pubmed: 28844373
J Proteome Res. 2017 Oct 6;16(10):3567-3575
pubmed: 28823163
Ostomy Wound Manage. 2003 Jan;49(1):54-62
pubmed: 12532034
Plast Reconstr Surg. 2001 Jan;107(1):229-37; discussion 238-9
pubmed: 11176628
Transfusion. 2010 Feb;50(2):501-6
pubmed: 19821947
Thromb Haemost. 2004 Jan;91(1):4-15
pubmed: 14691563
Ann Burns Fire Disasters. 2012 Dec 31;25(4):207-13
pubmed: 23766756
N Engl J Med. 1997 Aug 7;337(6):373-81
pubmed: 9241126
Blood Transfus. 2016 Jan;14(1):73-9
pubmed: 26509822
Biomaterials. 2016 Jan;76:371-87
pubmed: 26561934
Transfusion. 2014 Feb;54(2):340-52
pubmed: 23711284
Chonnam Med J. 2014 Dec;50(3):82-5
pubmed: 25568842
Platelets. 2018 Sep;29(6):556-568
pubmed: 29442539
Bone Marrow Transplant. 1998 Jun;21 Suppl 3:S43-7
pubmed: 9712493
Cell Transplant. 2015;24(12):2573-84
pubmed: 25695232
Biologicals. 2011 Mar;39(2):73-80
pubmed: 21353597
Bone Marrow Transplant. 2009 Nov;44(10):621-6
pubmed: 19802032
J Extra Corpor Technol. 2006 Jun;38(2):174-87
pubmed: 16921694
Cryobiology. 1999 May;38(3):209-24
pubmed: 10328911
Transfusion. 2019 Oct;59(10):3048-3050
pubmed: 31373684
Cornea. 2013 Apr;32(4):412-8
pubmed: 22955120
Eur J Immunol. 2015 Aug;45(8):2324-34
pubmed: 25991034
Thromb Haemost. 1998 May;79(5):885-96
pubmed: 9609215
J Phys Ther Sci. 2015 Dec;27(12):3863-7
pubmed: 26834369
Platelets. 2010;21(7):549-54
pubmed: 20873963
J Dent Res. 2005 May;84(5):434-9
pubmed: 15840779
Ostomy Wound Manage. 2006 Jun;52(6):68-70, 72, 74 passim
pubmed: 16799184
Blood Transfus. 2015 Jan;13(1):153-8
pubmed: 25369602