Rotenone restrains the proliferation, motility and epithelial-mesenchymal transition of colon cancer cells and the tumourigenesis in nude mice via PI3K/AKT pathway.
Animals
Carcinogenesis
/ drug effects
Cell Line, Tumor
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Colonic Neoplasms
/ pathology
Dose-Response Relationship, Drug
Epithelial-Mesenchymal Transition
/ drug effects
Humans
Mice
Phosphatidylinositol 3-Kinases
/ metabolism
Proto-Oncogene Proteins c-akt
/ metabolism
Rotenone
/ pharmacology
Xenograft Model Antitumor Assays
PI3K/AKT pathway
colon cancer
proliferation
rotenone
tumourigenesis
Journal
Clinical and experimental pharmacology & physiology
ISSN: 1440-1681
Titre abrégé: Clin Exp Pharmacol Physiol
Pays: Australia
ID NLM: 0425076
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
11
11
2019
revised:
15
03
2020
accepted:
30
03
2020
pubmed:
14
4
2020
medline:
13
10
2021
entrez:
14
4
2020
Statut:
ppublish
Résumé
Rotenone, a toxic rotenoid compound, has anti-tumour effects on several cancers. This study aims to clarify the effect of rotenone on the proliferation, apoptosis, invasion and migration of colon cancer cells and tumourigenesis in nude mice. The present results show that rotenone significantly inhibited the proliferation, promoted the apoptosis, and suppressed the invasion and migration of colon cancer cells in a dose-dependent manner. Rotenone inhibited PI3K/AKT pathway in LoVo and SW480 cells in a dose-dependent manner. In addition, rotenone regulated the proliferation, apoptosis, invasion, migration and EMT of LoVo and SW480 cells through PI3K/AKT pathway. In colon cancer xenograft mice, rotenone inhibited tumour volume and weight in nude mice, inhibited PI3K/AKT pathway and EMT in vivo. Therefore, rotenone inhibited the proliferation, invasion and migration, promoted the apoptosis of colon cancer cells through PI3K/AKT pathway in vitro, and suppressed the tumourigenesis in nude mice in vivo.
Identifiants
pubmed: 32282954
doi: 10.1111/1440-1681.13320
pmc: PMC7384028
doi:
Substances chimiques
Rotenone
03L9OT429T
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1484-1494Informations de copyright
© 2020 The Authors. Clinical and Experimental Pharmacology and Physiology published by John Wiley & Sons Australia, Ltd.
Références
J Pineal Res. 2017 Mar;62(2):
pubmed: 27865009
CA Cancer J Clin. 2018 Jan;68(1):7-30
pubmed: 29313949
Sci Rep. 2016 Jun 21;6:28388
pubmed: 27325206
Eur J Cancer. 2002 Dec;38(18):2446-54
pubmed: 12460790
Curr Drug Targets. 2019;20(12):1217-1226
pubmed: 31215384
World J Gastroenterol. 2017 Jul 28;23(28):5167-5178
pubmed: 28811711
J Exp Clin Cancer Res. 2018 Aug 13;37(1):189
pubmed: 30103781
Gut. 2013 Feb;62(2):259-71
pubmed: 22543158
J Transl Med. 2014 Aug 21;12:231
pubmed: 25141911
Eur J Pharmacol. 2018 Jan 15;819:58-67
pubmed: 29183837
Int J Mol Sci. 2015 Jul 24;16(8):16806-15
pubmed: 26213921
Clin Oncol (R Coll Radiol). 2017 Jul;29(7):459-465
pubmed: 28341242
Oncol Rep. 2017 Dec;38(6):3545-3553
pubmed: 29130099
Dis Colon Rectum. 2019 Feb;62(2):181-188
pubmed: 30640833
Dig Dis Sci. 2012 Nov;57(11):2873-82
pubmed: 22623043
Int J Radiat Biol. 2017 Jul;93(7):665-675
pubmed: 28281393
Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1118-28
pubmed: 26873970
Vet J. 2015 Aug;205(2):288-96
pubmed: 25975851
Neurotoxicology. 2015 Jan;46:101-16
pubmed: 25514659
Drug Discov Today. 2017 Aug;22(8):1224-1232
pubmed: 28545838
Carcinogenesis. 2012 Nov;33(11):2065-75
pubmed: 22847181
Cancer Biol Ther. 2009 Jul;8(13):1228-36
pubmed: 19411865
IUBMB Life. 2016 May;68(5):388-93
pubmed: 27015848
J Hematol Oncol. 2017 Jan 21;10(1):28
pubmed: 28109307
Clin Exp Pharmacol Physiol. 2020 Aug;47(8):1484-1494
pubmed: 32282954
Toxicol Lett. 2018 May 15;288:71-81
pubmed: 29458170
Cancer Lett. 2015 Feb 1;357(1):219-230
pubmed: 25444914
Int J Oncol. 2019 May;54(5):1691-1703
pubmed: 30816443
Oncotarget. 2016 Jun 21;7(25):38822-38834
pubmed: 27246978
BMC Cancer. 2015 May 02;15:346
pubmed: 25934296