The Phylum Bryozoa: From Biology to Biomedical Potential.
Alzheimer
anticancer
antiparasitic
antiviral
bryozoan
chemoecology
phylogeny
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
09 Apr 2020
09 Apr 2020
Historique:
received:
12
02
2020
revised:
31
03
2020
accepted:
06
04
2020
entrez:
15
4
2020
pubmed:
15
4
2020
medline:
14
1
2021
Statut:
epublish
Résumé
Less than one percent of marine natural products characterized since 1963 have been obtained from the phylum Bryozoa which, therefore, still represents a huge reservoir for the discovery of bioactive metabolites with its ~6000 described species. The current review is designed to highlight how bryozoans use sophisticated chemical defenses against their numerous predators and competitors, and which can be harbored for medicinal uses. This review collates all currently available chemoecological data about bryozoans and lists potential applications/benefits for human health. The core of the current review relates to the potential of bryozoan metabolites in human diseases with particular attention to viral, brain, and parasitic diseases. It additionally weighs the pros and cons of total syntheses of some bryozoan metabolites versus the synthesis of non-natural analogues, and explores the hopes put into the development of biotechnological approaches to provide sustainable amounts of bryozoan metabolites without harming the natural environment.
Identifiants
pubmed: 32283669
pii: md18040200
doi: 10.3390/md18040200
pmc: PMC7230173
pii:
doi:
Substances chimiques
Biological Products
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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