Mode of action of 3-butylidene phthalide as a competent natural pesticide.

Acetylcholinesterase Animals Benzofurans Cholinesterase Inhibitors Drosophila melanogaster Pesticides
AChE Molecular docking Phenol oxidase Phthalides Trihydroxy naphthalene reductase

Journal

Pesticide biochemistry and physiology
ISSN: 1095-9939
Titre abrégé: Pestic Biochem Physiol
Pays: United States
ID NLM: 1301573

Informations de publication

Date de publication:
Mar 2020
Historique:
received: 30 08 2019
revised: 29 01 2020
accepted: 01 02 2020
entrez: 15 4 2020
pubmed: 15 4 2020
medline: 16 4 2020
Statut: ppublish

Résumé

In this study, the biological activities and mode of action of 3-butylidene phthalide (3-BPH) were studied. 3-BPH had a superior efficiency against microsclerotia of Macrophomina phaseolina compared to the commercial fungicide tricyclazole. The microsclerotia formation and pigmentation were inhibited at 100 μg/mL. Moreover, the fungicide exhibited in silico affinity toward trihydroxy naphthalene reductase (3HNR). Both 3-BPH and tricyclazole showed congruence in the orientation and interaction within the 3HNR active site. 3-BPH displayed a strong interaction with SER-164, TYR-178, and TYR-223, with estimated binding energy and inhibition constant of -6.78 kcal mol

Identifiants

DOI: 10.1016/j.pestbp.2020.02.003 PMID: 32284131
pubmed: 32284131
pii: S0048-3575(20)30026-2
doi: 10.1016/j.pestbp.2020.02.003
pii:
doi:

Substances chimiques

Benzofurans 0
Cholinesterase Inhibitors 0
Pesticides 0
phthalide 8VV922U86J
Acetylcholinesterase EC 3.1.1.7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

228-236

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflict of interest.

Auteurs

Mohsen Abbod (M)

Department of Plant Pathology, Faculty of Agriculture, Tarbiat Modares University, P.O.B. 14115-336, Tehran, Iran.

Naser Safaie (N)

Department of Plant Pathology, Faculty of Agriculture, Tarbiat Modares University, P.O.B. 14115-336, Tehran, Iran. Electronic address: nsafaie@modares.ac.ir.

Khodayar Gholivand (K)

Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.

Mohammad Mehrabadi (M)

Department of Entomology, Faculty of Agriculture, Tarbiat Modares University, P.O. Box 14115-336, Tehran, Iran.

Mahyar Bonsaii (M)

Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Mode of action of 3-butylidene phthalide as a...
questionsmedicales.fr › Eucaryotes › Animaux › Mode of action of 3-butylidene phthalide as a...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzofuranes › Mode of action of 3-butylidene phthalide as a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Mode of action of 3-butylidene phthalide as a...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Mode of action of 3-butylidene phthalide as a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Mode of action of 3-butylidene phthalide as a...