Advances in Hereditary Angioedema: The Prevention of Angioedema Attacks With Subcutaneous C1-Inhibitor Replacement Therapy.

Angioedemas, Hereditary / drug therapy Clinical Trials as Topic Complement C1 Inhibitor Protein / administration & dosage Humans Injections, Subcutaneous Practice Guidelines as Topic Self Administration

Journal

Journal of infusion nursing : the official publication of the Infusion Nurses Society
ISSN: 1539-0667
Titre abrégé: J Infus Nurs
Pays: United States
ID NLM: 101124170

Informations de publication

Date de publication:
Historique:
entrez: 15 4 2020
pubmed: 15 4 2020
medline: 16 2 2021
Statut: ppublish

Résumé

Hereditary angioedema (HAE) is a debilitating condition caused by a functional C1-inhibitor (C1-INH) deficiency and characterized clinically by episodes of subcutaneous or submucosal swelling. C1-INH replacement is highly effective for preventing HAE attacks and can improve health-related quality of life. Once available only for intravenous use, C1-INH is now available as a subcutaneous formulation for self-administration, shown to provide sustained plasma levels of C1-INH and reducing the monthly median HAE attack rate by 95% versus placebo in the phase 3 COMPACT study. Subcutaneously administered C1-INH satisfies multiple unmet needs in the management of patients with HAE.

Identifiants

DOI: 10.1097/NAN.0000000000000365 PMID: 32287168 PMC: PMC7328861
pubmed: 32287168
doi: 10.1097/NAN.0000000000000365
pii: 00129804-202005000-00004
pmc: PMC7328861
doi:

Substances chimiques

Complement C1 Inhibitor Protein 0

Types de publication

Journal Article

Langues

eng

Pagination

134-145

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Auteurs

William Lumry (W)

AARA Research Center, Dallas, Texas (Dr Lumry); US HAEA Angioedema Center at University of California San Diego, San Diego, California (Ms Templeton); CSL Behring, King of Prussia, Pennsylvania (Dr Omert); University of California Irvine School of Medicine, Orange, California (Dr Levy).
William Lumry, MD, is in private practice in Dallas, Texas, treating adults and children with allergic diseases and asthma. He actively participates in clinical research projects involving new treatments for asthma, allergic and immune deficiency diseases, and hereditary angioedema in his role as medical director of AARA Research Center. He is also clinical professor of internal medicine at the University of Texas Southwestern Medical School in Dallas and teaches at Parkland Memorial Hospital in Dallas. Dr Lumry is president of the Texas Allergy, Asthma and Immunology Society and a fellow of the American Academy of Allergy, Asthma and Immunology, the American College of Allergy, Asthma and Immunology, and the American College of Physicians. He is also a member of the US Hereditary Angioedema Association Medical Advisory Board on the panels responsible for the Hereditary Angioedema International Working Group, International Consensus, and World Allergy Organization hereditary angioedema consensus documents.
Teri Templeton, LVN, was the nurse navigator and senior nurse supervisor of the US HAEA Angioedema Center at University of California San Diego, where she also served as the lead nurse on all clinical and translational research. As a public speaker and nurse educator, and through service on advisory boards, she worked to reduce the time to diagnosis and bring awareness to health care professionals on the signs and symptoms of hereditary angioedema.
Laurel Omert, MD, is currently chief medical officer at Hemanext in Lexington, Massachusetts, and a staff surgeon and intensivist at Albert Einstein Medical Center in Philadelphia. She served as medical director at CSL Behring for specialty products that included C1-INH(SC) and C1-INH(IV) during the development of this manuscript.
Donald Levy, MD, is a professor of medicine at University of California Irvine School of Medicine in Orange, California. He is very active in teaching students, residents, and fellows. He has a special interest in hereditary angioedema and conducts research in this field.

Teri Templeton (T)

AARA Research Center, Dallas, Texas (Dr Lumry); US HAEA Angioedema Center at University of California San Diego, San Diego, California (Ms Templeton); CSL Behring, King of Prussia, Pennsylvania (Dr Omert); University of California Irvine School of Medicine, Orange, California (Dr Levy).
William Lumry, MD, is in private practice in Dallas, Texas, treating adults and children with allergic diseases and asthma. He actively participates in clinical research projects involving new treatments for asthma, allergic and immune deficiency diseases, and hereditary angioedema in his role as medical director of AARA Research Center. He is also clinical professor of internal medicine at the University of Texas Southwestern Medical School in Dallas and teaches at Parkland Memorial Hospital in Dallas. Dr Lumry is president of the Texas Allergy, Asthma and Immunology Society and a fellow of the American Academy of Allergy, Asthma and Immunology, the American College of Allergy, Asthma and Immunology, and the American College of Physicians. He is also a member of the US Hereditary Angioedema Association Medical Advisory Board on the panels responsible for the Hereditary Angioedema International Working Group, International Consensus, and World Allergy Organization hereditary angioedema consensus documents.
Teri Templeton, LVN, was the nurse navigator and senior nurse supervisor of the US HAEA Angioedema Center at University of California San Diego, where she also served as the lead nurse on all clinical and translational research. As a public speaker and nurse educator, and through service on advisory boards, she worked to reduce the time to diagnosis and bring awareness to health care professionals on the signs and symptoms of hereditary angioedema.
Laurel Omert, MD, is currently chief medical officer at Hemanext in Lexington, Massachusetts, and a staff surgeon and intensivist at Albert Einstein Medical Center in Philadelphia. She served as medical director at CSL Behring for specialty products that included C1-INH(SC) and C1-INH(IV) during the development of this manuscript.
Donald Levy, MD, is a professor of medicine at University of California Irvine School of Medicine in Orange, California. He is very active in teaching students, residents, and fellows. He has a special interest in hereditary angioedema and conducts research in this field.

Laurel Omert (L)

AARA Research Center, Dallas, Texas (Dr Lumry); US HAEA Angioedema Center at University of California San Diego, San Diego, California (Ms Templeton); CSL Behring, King of Prussia, Pennsylvania (Dr Omert); University of California Irvine School of Medicine, Orange, California (Dr Levy).
William Lumry, MD, is in private practice in Dallas, Texas, treating adults and children with allergic diseases and asthma. He actively participates in clinical research projects involving new treatments for asthma, allergic and immune deficiency diseases, and hereditary angioedema in his role as medical director of AARA Research Center. He is also clinical professor of internal medicine at the University of Texas Southwestern Medical School in Dallas and teaches at Parkland Memorial Hospital in Dallas. Dr Lumry is president of the Texas Allergy, Asthma and Immunology Society and a fellow of the American Academy of Allergy, Asthma and Immunology, the American College of Allergy, Asthma and Immunology, and the American College of Physicians. He is also a member of the US Hereditary Angioedema Association Medical Advisory Board on the panels responsible for the Hereditary Angioedema International Working Group, International Consensus, and World Allergy Organization hereditary angioedema consensus documents.
Teri Templeton, LVN, was the nurse navigator and senior nurse supervisor of the US HAEA Angioedema Center at University of California San Diego, where she also served as the lead nurse on all clinical and translational research. As a public speaker and nurse educator, and through service on advisory boards, she worked to reduce the time to diagnosis and bring awareness to health care professionals on the signs and symptoms of hereditary angioedema.
Laurel Omert, MD, is currently chief medical officer at Hemanext in Lexington, Massachusetts, and a staff surgeon and intensivist at Albert Einstein Medical Center in Philadelphia. She served as medical director at CSL Behring for specialty products that included C1-INH(SC) and C1-INH(IV) during the development of this manuscript.
Donald Levy, MD, is a professor of medicine at University of California Irvine School of Medicine in Orange, California. He is very active in teaching students, residents, and fellows. He has a special interest in hereditary angioedema and conducts research in this field.

Donald Levy (D)

AARA Research Center, Dallas, Texas (Dr Lumry); US HAEA Angioedema Center at University of California San Diego, San Diego, California (Ms Templeton); CSL Behring, King of Prussia, Pennsylvania (Dr Omert); University of California Irvine School of Medicine, Orange, California (Dr Levy).
William Lumry, MD, is in private practice in Dallas, Texas, treating adults and children with allergic diseases and asthma. He actively participates in clinical research projects involving new treatments for asthma, allergic and immune deficiency diseases, and hereditary angioedema in his role as medical director of AARA Research Center. He is also clinical professor of internal medicine at the University of Texas Southwestern Medical School in Dallas and teaches at Parkland Memorial Hospital in Dallas. Dr Lumry is president of the Texas Allergy, Asthma and Immunology Society and a fellow of the American Academy of Allergy, Asthma and Immunology, the American College of Allergy, Asthma and Immunology, and the American College of Physicians. He is also a member of the US Hereditary Angioedema Association Medical Advisory Board on the panels responsible for the Hereditary Angioedema International Working Group, International Consensus, and World Allergy Organization hereditary angioedema consensus documents.
Teri Templeton, LVN, was the nurse navigator and senior nurse supervisor of the US HAEA Angioedema Center at University of California San Diego, where she also served as the lead nurse on all clinical and translational research. As a public speaker and nurse educator, and through service on advisory boards, she worked to reduce the time to diagnosis and bring awareness to health care professionals on the signs and symptoms of hereditary angioedema.
Laurel Omert, MD, is currently chief medical officer at Hemanext in Lexington, Massachusetts, and a staff surgeon and intensivist at Albert Einstein Medical Center in Philadelphia. She served as medical director at CSL Behring for specialty products that included C1-INH(SC) and C1-INH(IV) during the development of this manuscript.
Donald Levy, MD, is a professor of medicine at University of California Irvine School of Medicine in Orange, California. He is very active in teaching students, residents, and fellows. He has a special interest in hereditary angioedema and conducts research in this field.

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Maladies d'immunodéficience primaire › Déficits héréditaires en complément › Angio-oedèmes héréditaires › Advances in Hereditary Angioedema: The...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Advances in Hereditary Angioedema: The...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines inhibitrices de la fraction C1 du complément › C1 Inhibiteur › Advances in Hereditary Angioedema: The...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Advances in Hereditary Angioedema: The...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections sous-cutanées › Advances in Hereditary Angioedema: The...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Assurance de la qualité des soins de santé › Recommandations comme sujet › Guides de bonnes pratiques cliniques comme sujet › Advances in Hereditary Angioedema: The...
questionsmedicales.fr › Thérapeutique › Autoadministration › Advances in Hereditary Angioedema: The...