A glimpse at growth hormone-releasing hormone cosmos.
P53
endocrinology
endothelium
growth factors
inflammation
Journal
Clinical and experimental pharmacology & physiology
ISSN: 1440-1681
Titre abrégé: Clin Exp Pharmacol Physiol
Pays: Australia
ID NLM: 0425076
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
11
03
2020
accepted:
08
04
2020
pubmed:
15
4
2020
medline:
18
11
2021
entrez:
15
4
2020
Statut:
ppublish
Résumé
Growth hormone-releasing hormone is a hypothalamic neuropeptide, which regulates the secretion of growth hormone by the anterior pituitary gland. Recent evidence suggest that it exerts growth factor activities in a diverse variety of in vivo and in vitro experimental malignancies, which are counteracted by growth hormone-releasing hormone antagonists. Those peptides support lung endothelial barrier integrity by suppressing major inflammatory pathways and by inducing the endothelial defender P53. The present effort provides information regarding the effects of growth hormone-releasing hormone in the regulation of P53 and the unfolded protein response. Furthermore, it suggests the possible application of growth hormone-releasing hormone antagonists towards the management of acute lung injury, including the lethal acute respiratory distress syndrome.
Identifiants
pubmed: 32289177
doi: 10.1111/1440-1681.13324
pmc: PMC7426234
mid: NIHMS1586873
doi:
Substances chimiques
GHRH(1-29)NH2, (PhAc-Ada)(0)-Tyr(1), Arg(2), Fpa(5,6), Ala(8), Har(9), Tyr(Me)(10), His(11), Orn(12,) Abu(15), His(20), Orn(21), Nle(27), Arg(28), Har(29)-
0
Hormone Antagonists
0
Tumor Suppressor Protein p53
0
Sermorelin
86168-78-7
Growth Hormone-Releasing Hormone
9034-39-3
Types de publication
Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1632-1634Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103424
Pays : United States
Organisme : NIGMS NIH HHS
ID : 5 P20 GM103424-15
Pays : United States
Organisme : NIGMS NIH HHS
ID : 3 P20 GM103424-15S1
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons Australia, Ltd.
Références
IUBMB Life. 2020 Apr;72(4):801-804
pubmed: 32045095
Mol Psychiatry. 2020 Feb;25(2):275-282
pubmed: 31595035
Fertil Steril. 2010 Aug;94(3):841-9
pubmed: 19524226
Asian J Androl. 2015 Nov-Dec;17(6):923-4
pubmed: 26112485
Trends Endocrinol Metab. 2011 Aug;22(8):311-7
pubmed: 21530304
Endocrinology. 2019 Jul 1;160(7):1600-1612
pubmed: 31070727
Tissue Barriers. 2019;7(4):1669989
pubmed: 31578921
J Cell Mol Med. 2018 Mar;22(3):1792-1804
pubmed: 29363851
Eur J Pharmacol. 2013 Dec 5;721(1-3):294-300
pubmed: 24056124
Subcell Biochem. 2014;85:337-58
pubmed: 25201203
Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18303-8
pubmed: 25489106
Cold Spring Harb Perspect Med. 2016 Nov 1;6(11):
pubmed: 27549311
Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3755-60
pubmed: 21321192
Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2226-2231
pubmed: 30659154
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17424-9
pubmed: 16299104
Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20470-5
pubmed: 19075233
J Neuroinflammation. 2017 Nov 28;14(1):233
pubmed: 29179727
J Cell Biochem. 2019 Jul;120(7):10952-10955
pubmed: 30816605
Cell Stress Chaperones. 2020 Mar;25(2):195-197
pubmed: 31950341
Cell Signal. 2020 Mar;67:109500
pubmed: 31837463
Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14396-14401
pubmed: 27911838
Cell Cycle. 2010 Oct 15;9(20):4110-6
pubmed: 20962577
Sci Rep. 2020 Jan 20;10(1):732
pubmed: 31959947
Nature. 2008 Jul 24;454(7203):436-44
pubmed: 18650914
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9512-7
pubmed: 12867592
Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6067-6074
pubmed: 32123064
Vitam Horm. 2005;70:1-24
pubmed: 15727800
Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L776-87
pubmed: 25713322
Nat Rev Dis Primers. 2016 May 05;2:16031
pubmed: 27147135
Front Cell Neurosci. 2018 Jul 27;12:222
pubmed: 30104960
Rev Prat. 2005;Spec. No:5-7
pubmed: 15822862
Cell Cycle. 2020 Jan;19(2):160-162
pubmed: 31880200
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1359-1364
pubmed: 28123062
J Biochem Mol Toxicol. 2019 Oct;33(10):e22380
pubmed: 31339623
J Clin Endocrinol Metab. 1999 Feb;84(2):582-9
pubmed: 10022420
Lung. 2019 Oct;197(5):541-549
pubmed: 31392398
Inflammation. 2020 Apr;43(2):686-691
pubmed: 31838664
Prostate. 2010 Jul 1;70(10):1087-93
pubmed: 20232355
J Clin Endocrinol Metab. 1999 Dec;84(12):4671-6
pubmed: 10599736
Br J Cancer. 2008 Jun 3;98(11):1790-6
pubmed: 18506184
Growth Horm IGF Res. 1999 Apr;9 Suppl A:37-44
pubmed: 10429879
Endocrinology. 1961 Aug;69:225-30
pubmed: 13740467
Rev Prat. 2005;Spec. No:20-4
pubmed: 15822866
Curr Mol Med. 2016;16(3):299-311
pubmed: 26917260
Aging (Albany NY). 2012 Nov;4(11):755-67
pubmed: 23211425
Biochimie. 2019 Oct;165:206-209
pubmed: 31404589