Terpenylated coumarins from the root bark of Ailanthus altissima (Mill.) Swingle.

Ailanthus Coumarins Plant Bark Plant Extracts
Ailanthus altissima (Mill.) Swingle Modified Mosher's method NMR calculation Simaroubaceae Terpenylated coumarins

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Jul 2020
Historique:
received: 05 05 2019
revised: 18 03 2020
accepted: 19 03 2020
pubmed: 15 4 2020
medline: 10 6 2020
entrez: 15 4 2020
Statut: ppublish

Résumé

Seven undescribed terpenylated coumarins, named altissimacoumarin I-O, together with seven known compounds, altissimacoumarin C, altissimacoumarin E, altissimacoumarin G, altissimacoumarin H, puberulin, 7-(3-Methyl-2-butenyloxy)-6-methoxycoumarin and artelin were isolated from the root bark of Ailanthus altissima (Mill.) Swingle. Their structures were elucidated by comprehensive spectra data analysis, NMR calculation, DP4+ analysis and ACD/Structure Elucidator software simulation. The absolute configurations of altissimacoumarins K, L, M and N were determined by modified Mosher's method. All isolates were tested for their cytotoxic effect against two hepatoma carcinoma cell lines (HepG2, Hep3B). Altissimacoumarin C exhibited moderate cytotoxic effect against Hep3B cells, with IC

Identifiants

DOI: 10.1016/j.phytochem.2020.112361 PMID: 32289598
pubmed: 32289598
pii: S0031-9422(19)30399-1
doi: 10.1016/j.phytochem.2020.112361
pii:
doi:

Substances chimiques

Coumarins 0
Plant Extracts 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112361

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Zhi-Yang Yan (ZY)

School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.

Tian-Ming Lv (TM)

School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.

Yu-Xi Wang (YX)

School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.

Shao-Chun Shi (SC)

School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.

Jing-Jie Chen (JJ)

School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.

Qing-Bo Liu (QB)

School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.

Xiao-Xiao Huang (XX)

School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China. Electronic address: xiaoxiao270@163.com.

Shao-Jiang Song (SJ)

School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Simaroubaceae › Ailanthus › Terpenylated coumarins from the root bark of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Coumarines › Terpenylated coumarins from the root bark of...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Épiderme végétal › Écorce › Terpenylated coumarins from the root bark of...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Terpenylated coumarins from the root bark of...