Optimization of Ultrasound-Assisted Extraction Using Response Surface Methodology for Simultaneous Quantitation of Six Flavonoids in Flos Sophorae Immaturus and Antioxidant Activity.
HPLC
antioxidant activity
flavonoids
flos sophorae immaturus
ultrasound-assisted extraction
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
12 Apr 2020
12 Apr 2020
Historique:
received:
02
03
2020
revised:
07
04
2020
accepted:
08
04
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
8
1
2021
Statut:
epublish
Résumé
Ultrasound-assisted extraction (UAE) was applied to extract rutin (RU), nicotiflorin (NI), narcissoside (NA), kaempferol (KA), isorhamnetin (IS), quercetin (QU), and total flavonoids of Flos Sophorae Immaturus (TFFSI) from Flos Sophorae Immaturus (FSI). Through single factor test and response surface methodology (RSM), the optimal extraction conditions were concluded as follows: ethanol concentration 70%, time 30 min, temperature 61 °C, and liquid/solid ratio 15.30 mL/g, respectively. The actual extraction rates of RU, NI, NA, KA, IS, QU, and TFFSI were 14.6101%, 2.9310%, 7.1987%, 0.1041%, 0.4920%, 2.7998%, and 26.4260%, respectively. The experimental results demonstrated that the extraction method with accuracy and efficiency could be used for the comprehensive evaluation quality control of extracts from FSI. The antioxidant activities of hydroalcoholic extraction from FSI on 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•
Identifiants
pubmed: 32290627
pii: molecules25081767
doi: 10.3390/molecules25081767
pmc: PMC7221660
pii:
doi:
Substances chimiques
Antioxidants
0
Drugs, Chinese Herbal
0
Flavonoids
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Higher Education Institution Project of Shanxi Province: Ecological Remediation of Soil Pollution Disciplines Group
ID : No.20181401
Organisme : The Key research and development projects of Shanxi Province
ID : 201703D211019, 201703D211012-1
Organisme : 2019 Graduate Education Innovation Program Project
ID : 2019SY011
Organisme : Shanxi characteristic biological resources and health industry collaborative innovation center for "1331 Project" in Shanxi Province
ID : 2017
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