Association of Serum Uromodulin with Death, Cardiovascular Events, and Kidney Failure in CKD.
Tamm–Horsfall protein
albuminuria
cardiovascular diseases
chronic
chronic kidney disease
confidence intervals
coronary angiography
coronary artery disease
diabetes mellitus
end-stage renal disease
epithelial cells
glomerular filtration rate
hypertension
myocardial infarction
peripheral vascular diseases
regression analysis
renal insufficiency
risk factors
stroke
tubular function
uromodulin
Journal
Clinical journal of the American Society of Nephrology : CJASN
ISSN: 1555-905X
Titre abrégé: Clin J Am Soc Nephrol
Pays: United States
ID NLM: 101271570
Informations de publication
Date de publication:
07 05 2020
07 05 2020
Historique:
received:
30
09
2019
accepted:
10
02
2020
pubmed:
16
4
2020
medline:
10
9
2021
entrez:
16
4
2020
Statut:
ppublish
Résumé
Uromodulin is exclusively produced by tubular epithelial cells and released into urine and serum. Higher serum uromodulin has been associated with lower risk for kidney failure in Chinese patients with CKD and with lower risk for mortality in the elderly and in patients undergoing coronary angiography. We hypothesized that lower serum uromodulin is associated with mortality, cardiovascular events, and kidney failure in white patients with CKD. We measured serum uromodulin in 5143 participants enrolled in the German CKD (GCKD) study. The associations of baseline serum uromodulin with all-cause mortality, major adverse cardiovascular events (MACE; a composite of cardiovascular mortality, nonfatal myocardial infarction or stroke, or incident peripheral vascular disease), and kidney failure (dialysis or transplantation) were evaluated using multivariable Cox proportional hazard regression analyses in a cohort study design, adjusting for demographics, eGFR, albuminuria, cardiovascular risk factors, and medication. The mean age of participants was 60±12 years, 60% were male. Mean serum uromodulin concentration was 98±60 ng/ml, eGFR was 49±18 ml/min per 1.73 m Higher serum uromodulin is independently associated with lower risk for mortality, cardiovascular events, and kidney failure in white patients with CKD. Deutsches Register für Klinische Studien (DRKS; German national database of clinical studies), DRKS00003971.
Sections du résumé
BACKGROUND AND OBJECTIVES
Uromodulin is exclusively produced by tubular epithelial cells and released into urine and serum. Higher serum uromodulin has been associated with lower risk for kidney failure in Chinese patients with CKD and with lower risk for mortality in the elderly and in patients undergoing coronary angiography. We hypothesized that lower serum uromodulin is associated with mortality, cardiovascular events, and kidney failure in white patients with CKD.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS
We measured serum uromodulin in 5143 participants enrolled in the German CKD (GCKD) study. The associations of baseline serum uromodulin with all-cause mortality, major adverse cardiovascular events (MACE; a composite of cardiovascular mortality, nonfatal myocardial infarction or stroke, or incident peripheral vascular disease), and kidney failure (dialysis or transplantation) were evaluated using multivariable Cox proportional hazard regression analyses in a cohort study design, adjusting for demographics, eGFR, albuminuria, cardiovascular risk factors, and medication.
RESULTS
The mean age of participants was 60±12 years, 60% were male. Mean serum uromodulin concentration was 98±60 ng/ml, eGFR was 49±18 ml/min per 1.73 m
CONCLUSIONS
Higher serum uromodulin is independently associated with lower risk for mortality, cardiovascular events, and kidney failure in white patients with CKD.
CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER
Deutsches Register für Klinische Studien (DRKS; German national database of clinical studies), DRKS00003971.
Identifiants
pubmed: 32291270
pii: 01277230-202005000-00009
doi: 10.2215/CJN.11780919
pmc: PMC7269219
doi:
Substances chimiques
Biomarkers
0
UMOD protein, human
0
Uromodulin
0
Banques de données
DRKS
['DRKS00003971']
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
616-624Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 by the American Society of Nephrology.
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