A Heterotrimeric Dehydrogenase Complex Functions with 2 Distinct YcaO Proteins to Install 5 Azole Heterocycles into 35-Membered Sulfomycin Thiopeptides.

Azoles / chemistry Bacterial Proteins / chemistry Molecular Structure Oxidoreductases / chemistry Peptides / chemistry Streptomyces / enzymology Sulfhydryl Compounds / chemistry

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
06 05 2020
Historique:
pubmed: 16 4 2020
medline: 14 4 2021
entrez: 16 4 2020
Statut: ppublish

Résumé

Sulfomycins are sulfur-rich, ribosomally synthesized, and post-translationally modified peptides (RiPPs) that are characterized by a 35-membered macrocyclic ring system with a pyridine domain central to five azoles and additional dehydroamino acids. The pathway through which these large thiopeptide antibiotics are formed in

Identifiants

DOI: 10.1021/jacs.0c02329 PMID: 32293883
pubmed: 32293883
doi: 10.1021/jacs.0c02329
doi:

Substances chimiques

Azoles 0
Bacterial Proteins 0
Peptides 0
Sulfhydryl Compounds 0
sulfomycin 65454-59-3
Oxidoreductases EC 1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8454-8463

Commentaires et corrections

Type : ErratumIn

Auteurs

Yanan Du (Y)

State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.

Yanping Qiu (Y)

State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
ORCID: 0000-0003-2948-2173

Xiang Meng (X)

State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.

Junyin Feng (J)

Huzhou Center of Bio-Synthetic Innovation, 1366 Hongfeng Road, Huzhou 313000, China.

Jiang Tao (J)

Department of General Dentistry, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai 200011, China.

Wen Liu (W)

State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Huzhou Center of Bio-Synthetic Innovation, 1366 Hongfeng Road, Huzhou 313000, China.
ORCID: 0000-0003-2729-1787

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › A Heterotrimeric Dehydrogenase Complex...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › A Heterotrimeric Dehydrogenase Complex...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › A Heterotrimeric Dehydrogenase Complex...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › A Heterotrimeric Dehydrogenase Complex...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › A Heterotrimeric Dehydrogenase Complex...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Streptomycetaceae › Streptomyces › A Heterotrimeric Dehydrogenase Complex...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiols › A Heterotrimeric Dehydrogenase Complex...