Effects of Acute Colchicine Administration Prior to Percutaneous Coronary Intervention: COLCHICINE-PCI Randomized Trial.
Acute Coronary Syndrome
/ diagnostic imaging
Administration, Oral
Aged
Anti-Inflammatory Agents
/ administration & dosage
Biomarkers
/ blood
C-Reactive Protein
/ metabolism
Colchicine
/ administration & dosage
Coronary Artery Disease
/ diagnostic imaging
Double-Blind Method
Drug Administration Schedule
Female
Humans
Inflammation
/ blood
Inflammation Mediators
/ blood
Interleukin-6
/ blood
Male
Middle Aged
New York City
Percutaneous Coronary Intervention
/ adverse effects
Prospective Studies
Risk Factors
Stents
Time Factors
Treatment Outcome
biomarker
colchicine
inflammation
myocardial infarction
percutaneous coronary intervention
Journal
Circulation. Cardiovascular interventions
ISSN: 1941-7632
Titre abrégé: Circ Cardiovasc Interv
Pays: United States
ID NLM: 101499602
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
entrez:
17
4
2020
pubmed:
17
4
2020
medline:
11
11
2020
Statut:
ppublish
Résumé
Vascular injury and inflammation during percutaneous coronary intervention (PCI) are associated with increased risk of post-PCI adverse outcomes. Colchicine decreases neutrophil recruitment to sites of vascular injury. The anti-inflammatory effects of acute colchicine administration before PCI on subsequent myocardial injury are unknown. In a prospective, single-site trial, subjects referred for possible PCI (n=714) were randomized to acute preprocedural oral administration of colchicine 1.8 mg or placebo. Among the 400 subjects who underwent PCI, the primary outcome of PCI-related myocardial injury did not differ between colchicine (n=206) and placebo (n=194) groups (57.3% versus 64.2%, Acute preprocedural administration of colchicine attenuated the increase in interleukin-6 and high-sensitivity C-reactive protein concentrations after PCI when compared with placebo but did not lower the risk of PCI-related myocardial injury. Registration: URL: https://www.clinicaltrials.gov; Unique Identifiers: NCT02594111, NCT01709981.
Sections du résumé
BACKGROUND
Vascular injury and inflammation during percutaneous coronary intervention (PCI) are associated with increased risk of post-PCI adverse outcomes. Colchicine decreases neutrophil recruitment to sites of vascular injury. The anti-inflammatory effects of acute colchicine administration before PCI on subsequent myocardial injury are unknown.
METHODS
In a prospective, single-site trial, subjects referred for possible PCI (n=714) were randomized to acute preprocedural oral administration of colchicine 1.8 mg or placebo.
RESULTS
Among the 400 subjects who underwent PCI, the primary outcome of PCI-related myocardial injury did not differ between colchicine (n=206) and placebo (n=194) groups (57.3% versus 64.2%,
CONCLUSIONS
Acute preprocedural administration of colchicine attenuated the increase in interleukin-6 and high-sensitivity C-reactive protein concentrations after PCI when compared with placebo but did not lower the risk of PCI-related myocardial injury. Registration: URL: https://www.clinicaltrials.gov; Unique Identifiers: NCT02594111, NCT01709981.
Identifiants
pubmed: 32295417
doi: 10.1161/CIRCINTERVENTIONS.119.008717
pmc: PMC7169992
mid: NIHMS1567455
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Biomarkers
0
IL6 protein, human
0
Inflammation Mediators
0
Interleukin-6
0
C-Reactive Protein
9007-41-4
Colchicine
SML2Y3J35T
Banques de données
ClinicalTrials.gov
['NCT02594111', 'NCT01709981']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e008717Subventions
Organisme : CSRD VA
ID : IK2 CX001074
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016087
Pays : United States
Commentaires et corrections
Type : CommentIn
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