Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4

Antigens, Neoplasm / immunology CD4-Positive T-Lymphocytes / immunology Cell Line, Tumor Extracellular Vesicles / immunology Humans Immunotherapy, Adoptive Neuroblastoma / immunology Receptors, Chimeric Antigen / immunology
immunotherapy neuroblastoma neurotrophic receptor tyrosine kinase pediatric oncology solid tumors

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2020
Historique:
received: 13 12 2019
accepted: 09 03 2020
entrez: 17 4 2020
pubmed: 17 4 2020
medline: 27 3 2021
Statut: epublish

Résumé

Chimeric antigen receptor (CAR) T cell efficacy against solid tumors is currently limited by several immune escape mechanisms, which may include tumor-derived extracellular vesicles. Advanced neuroblastoma is an aggressive childhood tumor without curative treatment options for most relapsed patients today. We here evaluated the role of tumor-derived extracellular vesicles on the efficacy of CAR T cells targeting the neuroblastoma-specific antigen, CD171. For this purpose, CAR T cell activation, cytokine production, exhaustion, and tumor cell-directed cytotoxicity upon co-culture was evaluated. Tumor-derived extracellular vesicles isolated from SH-SY5Y neuroblastoma cells neither affected CAR T cell activation nor expression of inhibitory markers. Importantly, exposure of CD4

Identifiants

DOI: 10.3389/fimmu.2020.00531 PMID: 32296437 PMC: PMC7137471
pubmed: 32296437
doi: 10.3389/fimmu.2020.00531
pmc: PMC7137471
doi:

Substances chimiques

Antigens, Neoplasm 0
Receptors, Chimeric Antigen 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

531

Informations de copyright

Copyright © 2020 Ali, Toews, Schwiebert, Klaus, Winkler, Grunewald, Oevermann, Deubzer, Tüns, Jensen, Henssen, Eggert, Schulte, Schwich, Rebmann, Schramm and Künkele.

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Auteurs

Solin Ali (S)

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Karin Toews (K)

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Silke Schwiebert (S)

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Anika Klaus (A)

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Annika Winkler (A)

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Laura Grunewald (L)

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Lena Oevermann (L)

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.

Hedwig E Deubzer (HE)

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Neuroblastoma Research Group, Experimental and Clinical Research Center (ECRC) of the Charité and the Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany.
German Cancer Consortium (DKTK), Heidelberg, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany.

Alicia Tüns (A)

Department of Internal Medicine, University Duisburg-Essen, Essen, Germany.

Michael C Jensen (MC)

Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, United States.
Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
University of Washington, Department of Bioengineering, Seattle, WA, United States.

Anton G Henssen (AG)

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.

Angelika Eggert (A)

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.
German Cancer Consortium (DKTK), Heidelberg, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany.

Johannes H Schulte (JH)

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
German Cancer Consortium (DKTK), Heidelberg, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany.

Esther Schwich (E)

Department of Transfusion Medicine, University Duisburg-Essen, Essen, Germany.

Vera Rebmann (V)

Department of Transfusion Medicine, University Duisburg-Essen, Essen, Germany.

Alexander Schramm (A)

Department of Internal Medicine, University Duisburg-Essen, Essen, Germany.

Annette Künkele (A)

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.
German Cancer Consortium (DKTK), Heidelberg, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes néoplasiques › Tumor-Derived Extracellular Vesicles Impair...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Tumor-Derived Extracellular Vesicles Impair...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Tumor-Derived Extracellular Vesicles Impair...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Tumor-Derived Extracellular Vesicles Impair...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tumor-Derived Extracellular Vesicles Impair...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Immunothérapie adoptive › Tumor-Derived Extracellular Vesicles Impair...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Tumeurs neuroectodermiques primitives › Tumeurs neuroectodermiques primitives périphériques › Neuroblastome › Tumor-Derived Extracellular Vesicles Impair...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs chimériques pour l'antigène › Tumor-Derived Extracellular Vesicles Impair...