Oligonucleotides: Current Trends and Innovative Applications in the Synthesis, Characterization, and Purification.
biopharmaceuticals
chromatography
continuous chromatography
drugs
gene therapy
multicolumn solvent gradient process
oligonucleotides
solid-phase
Journal
Biotechnology journal
ISSN: 1860-7314
Titre abrégé: Biotechnol J
Pays: Germany
ID NLM: 101265833
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
22
01
2020
revised:
17
03
2020
pubmed:
17
4
2020
medline:
27
2
2021
entrez:
17
4
2020
Statut:
ppublish
Résumé
Oligonucleotides (ONs) are gaining increasing importance as a promising novel class of biopharmaceuticals. Thanks to their fundamental role in gene regulation, they can be used to develop custom-made drugs (also called N-to-1) able to act on the gene expression at pre-translational level. With recent approvals of ON-based therapeutics by the Food and Drug Administration (FDA), a growing demand for high-quality chemically modified ONs is emerging and their market is expected to impressively prosper in the near future. To satisfy this growing market demand, a scalable and economically sustainable ON production is needed. In this paper, the state of the art of the whole ON production process is illustrated with the aim of highlighting the most promising routes toward the auspicated market-size production. In particular, the most recent advancements in both the upstream stage, mainly based on solid-phase synthesis and recombinant technology, and the downstream one, focusing on chromatographic techniques, are reviewed. Since ON production is projected to expand to the large scale, automatized multicolumn countercurrent technologies will reasonably be required soon to replace the current ones based on batch single-column operations. This consideration is supported by a recent cutting-edge application of continuous chromatography for the ON purification.
Identifiants
pubmed: 32298041
doi: 10.1002/biot.201900226
doi:
Substances chimiques
Biological Products
0
Oligonucleotides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900226Subventions
Organisme : Italian University and Scientific Research Ministry
ID : PRIN 2017Y2PAB8 003
Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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