Massimo Morbidelli

Affiliations

Institute for Chemical and Bioengineering, ETH Zurich, Vladimir-Prelog-Weg 1, 8093 Zurich, Switzerland.

Publications (38)

From batch to continuous chromatographic purification of a therapeutic peptide through multicolumn countercurrent solvent gradient purification.

Journal of chromatography. A

Avec: Chiara De Luca , Simona Felletti , Giulio Lievore , Alessandro Buratti , Sebastian Vogg , Massimo Morbidelli , Alberto Cavazzini , Martina Catani , Marco Macis , Antonio Ricci , Walter Cabri

Understanding mAb aggregation during low pH viral inactivation and subsequent neutralization.

Biotechnology and bioengineering

Avec: Ruben Wälchli , Mariana Ressurreição , Sebastian Vogg , Fabian Feidl , James Angelo , Xuankuo Xu , Sanchayita Ghose , Zheng Jian Li , Xavier Le Saoût , Jonathan Souquet , Hervé Broly , Massimo Morbidelli

Process-wide control and automation of an integrated continuous manufacturing platform for antibodies.

Biotechnology and bioengineering

Avec: Fabian Feidl , Sebastian Vogg , Moritz Wolf , Matevz Podobnik , Caterina Ruggeri , Nicole Ulmer , Ruben Wälchli , Jonathan Souquet , Hervé Broly , Alessandro Butté , Massimo Morbidelli

Improved Performance in Mammalian Cell Perfusion Cultures by Growth Inhibition.

Biotechnology journal

Avec: Moritz K F Wolf , Aurélie Closet , Monika Bzowska , Jean-Marc Bielser , Jonathan Souquet , Hervé Broly , Massimo Morbidelli

Transcriptome and proteome analysis of steady-state in a perfusion CHO cell culture process.

Biotechnology and bioengineering

Avec: Vania Bertrand , Daniel J Karst , Alessia Bachmann , Katia Cantalupo , Miroslav Soos , Massimo Morbidelli

Macroporous Polymer⁻Protein Hybrid Materials for Antibody Purification by Combination of Reactive Gelation and Click-Chemistry.

Materials (Basel, Switzerland)

Avec: Marcel Lorenz , Carolina Paganini , Giuseppe Storti , Massimo Morbidelli

Expansion processes for cell-based therapies.

Biotechnology advances

Avec: Ernesto Scibona , Massimo Morbidelli

Perfusion cell culture for the production of conjugated recombinant fusion proteins reduces clipping and quality heterogeneity compared to batch-mode processes.

Journal of biotechnology

Avec: Jean-Marc Bielser , Loïc Chappuis , Yashi Xiao , Jonathan Souquet , Hervé Broly , Massimo Morbidelli

Soft sensor based on Raman spectroscopy for the in-line monitoring of metabolites and polymer quality in the biomanufacturing of polyhydroxyalkanoates.

Journal of biotechnology

Avec: João Medeiros Garcia Alcântara , Francesco Iannacci , Massimo Morbidelli , Mattia Sponchioni

Readily Adsorbable Thermoresponsive Polymers for the Preparation of Smart Cell-Culturing Surfaces on Site.

ACS biomaterials science & engineering

Avec: Mattia Sponchioni , Nicolò Manfredini , Arianna Zanoni , Ernesto Scibona , Massimo Morbidelli , Davide Moscatelli

Analysis and optimal design of batch and two-column continuous chromatographic frontal processes for monoclonal antibody purification.

Biotechnology and bioengineering

Avec: Ce Shi , Sebastian Vogg , Dong-Qiang Lin , Mattia Sponchioni , Massimo Morbidelli

Recovery of Mineral Oil from Underground Electrical Cables.

International journal of environmental research and public health

Avec: Stefano Caimi , Claudio Colombo , Raffaele Ferrari , Giuseppe Storti , Massimo Morbidelli

Bioprocessing in the Digital Age: The Role of Process Models.

Biotechnology journal

Avec: Harini Narayanan , Martin F Luna , Moritz von Stosch , Mariano Nicolas Cruz Bournazou , Gianmarco Polotti , Massimo Morbidelli , Alessandro Butté , Michael Sokolov

Semi-continuous scale-down models for clone and operating parameter screening in perfusion bioreactors.

Biotechnology progress

Avec: Jean-Marc Bielser , Jakub Domaradzki , Jonathan Souquet , Hervé Broly , Massimo Morbidelli

Model-assisted process characterization and validation for a continuous two-column protein A capture process.

Biotechnology and bioengineering

Avec: Daniel Baur , James Angelo , Srinivas Chollangi , Thomas Müller-Späth , Xuankuo Xu , Sanchayita Ghose , Zheng Jian Li , Massimo Morbidelli

Purification of Human Monoclonal Antibodies and Their Fragments.

Methods in molecular biology (Clifton, N.J.)

Avec: Nicole Ulmer , Sebastian Vogg , Thomas Müller-Späth , Massimo Morbidelli

Hybrid Models for the simulation and prediction of chromatographic processes for protein capture.

Journal of chromatography. A

Avec: Harini Narayanan , Tobias Seidler , Martin Francisco Luna , Michael Sokolov , Massimo Morbidelli , Alessandro Butté

Modeling the nonlinear behavior of a bioactive peptide in reversed-phase gradient elution chromatography.

Journal of chromatography. A

Avec: Chiara De Luca , Simona Felletti , Marco Macis , Walter Cabri , Giulio Lievore , Tatiana Chenet , Luisa Pasti , Massimo Morbidelli , Alberto Cavazzini , Martina Catani , Antonio Ricci

Design space and robustness analysis of batch and counter-current frontal chromatography processes for the removal of antibody aggregates.

Journal of chromatography. A

Avec: Sebastian Vogg , Thomas Müller-Späth , Massimo Morbidelli

Monitoring of antibody glycosylation pattern based on microarray MALDI-TOF mass spectrometry.

Journal of biotechnology

Avec: Joanna Hajduk , Moritz Wolf , Robert Steinhoff , Daniel Karst , Jonathan Souquet , Hervé Broly , Massimo Morbidelli , Renato Zenobi

Experimental Evaluation of the Impact of Intrinsic Process Parameters on the Performance of a Continuous Chromatographic Polishing Unit (MCSGP).

Biotechnology journal

Avec: Sebastian Vogg , Nicole Ulmer , Jonathan Souquet , Hervé Broly , Massimo Morbidelli

Oligonucleotides: Current Trends and Innovative Applications in the Synthesis, Characterization, and Purification.

Biotechnology journal

Avec: Martina Catani , Chiara De Luca , João Medeiros Garcia Alcântara , Nicolò Manfredini , Daniela Perrone , Elena Marchesi , Richard Weldon , Thomas Müller-Späth , Alberto Cavazzini , Massimo Morbidelli , Mattia Sponchioni

Role of the gradient slope during the product internal recycling for the multicolumn countercurrent solvent gradient purification of PEGylated proteins.

Journal of chromatography. A

Avec: Tae Keun Kim , Abdallah Ayub Bham , Ismaele Fioretti , James Angelo , Xuankuo Xu , Sanchayita Ghose , Massimo Morbidelli , Mattia Sponchioni

Cell culture process metabolomics together with multivariate data analysis tools opens new routes for bioprocess development and glycosylation prediction.

Biotechnology progress

Avec: Philipp Zürcher , Michael Sokolov , David Brühlmann , Raphael Ducommun , Matthieu Stettler , Jonathan Souquet , Martin Jordan , Hervé Broly , Massimo Morbidelli , Alessandro Butté

Model based strategies towards protein A resin lifetime optimization and supervision.

Journal of chromatography. A

Avec: Fabian Feidl , Martin F Luna , Matevz Podobnik , Sebastian Vogg , James Angelo , Kevin Potter , Elenore Wiggin , Xuankuo Xu , Sanchayita Ghose , Zheng Jian Li , Massimo Morbidelli , Alessandro Butté

Development of Mammalian Cell Perfusion Cultures at Lab Scale: From Orbitally Shaken Tubes to Benchtop Bioreactors.

Methods in molecular biology (Clifton, N.J.)

Avec: Moritz Wolf , Massimo Morbidelli

Process for Continuous Fab Production by Digestion of IgG.

Biotechnology journal

Avec: Nicole Ulmer , Dragana Ristanovic , Massimo Morbidelli

Process design and development of a mammalian cell perfusion culture in shake-tube and benchtop bioreactors.

Biotechnology and bioengineering

Avec: Moritz K F Wolf , Andrea Müller , Jonathan Souquet , Hervé Broly , Massimo Morbidelli

Decision Tree-PLS (DT-PLS) algorithm for the development of process: Specific local prediction models.

Biotechnology progress

Avec: Harini Narayanan , Michael Sokolov , Alessandro Butté , Massimo Morbidelli

Modern trends in downstream processing of biotherapeutics through continuous chromatography: The potential of Multicolumn Countercurrent Solvent Gradient Purification.

Trends in analytical chemistry : TRAC

Avec: Chiara De Luca , Simona Felletti , Giulio Lievore , Tatiana Chenet , Massimo Morbidelli , Mattia Sponchioni , Alberto Cavazzini , Martina Catani

Continuous countercurrent chromatographic twin-column purification of oligonucleotides: The role of the displacement effect.

Biotechnology and bioengineering

Avec: Ismaele Fioretti , Thomas Müller-Späth , Richard Weldon , Sebastian Vogg , Massimo Morbidelli , Mattia Sponchioni

Design and economic investigation of a Multicolumn Countercurrent Solvent Gradient Purification unit for the separation of an industrially relevant PEGylated protein.

Journal of chromatography. A

Avec: Tae Keun Kim , Benedetta Sechi , Juan Jose Romero Conde , James Angelo , Xuankuo Xu , Sanchayita Ghose , Massimo Morbidelli , Mattia Sponchioni

A new flow cell and chemometric protocol for implementing in-line Raman spectroscopy in chromatography.

Biotechnology progress

Avec: Fabian Feidl , Simone Garbellini , Sebastian Vogg , Michael Sokolov , Jonathan Souquet , Hervé Broly , Alessandro Butté , Massimo Morbidelli

A new generation of predictive models: The added value of hybrid models for manufacturing processes of therapeutic proteins.

Biotechnology and bioengineering

Avec: Harini Narayanan , Michael Sokolov , Massimo Morbidelli , Alessandro Butté

Current trends in the production of biodegradable bioplastics: The case of polyhydroxyalkanoates.

Biotechnology advances

Avec: João Medeiros Garcia Alcântara , Francesco Distante , Giuseppe Storti , Davide Moscatelli , Massimo Morbidelli , Mattia Sponchioni

Process intensification by frontal chromatography: Performance comparison of resin and membrane adsorber for monovalent antibody aggregate removal.

Biotechnology and bioengineering

Avec: Sebastian Vogg , Felix Pfeifer , Nicole Ulmer , Massimo Morbidelli

Hybrid-EKF: Hybrid model coupled with extended Kalman filter for real-time monitoring and control of mammalian cell culture.

Biotechnology and bioengineering

Avec: Harini Narayanan , Lars Behle , Martin F Luna , Michael Sokolov , Gonzalo Guillén-Gosálbez , Massimo Morbidelli , Alessandro Butté

High-Density Perfusion Cultures of the Marine Bacterium Rhodovulum sulfidophilum for the Biomanufacturing of Oligonucleotides.

Journal of biotechnology

Avec: Francesco Iannacci , João Medeiros Garcia Alcântara , Martina Marani , Paolo Camesasca , Michele Chen , Fani Sousa , Massimo Morbidelli , Mattia Sponchioni

Réseau de co-auteurs

Sebastian Vogg 11 collaborations

Jonathan Souquet 10 collaborations

Hervé Broly 10 collaborations

Mattia Sponchioni 10 collaborations

Alessandro Butté 9 collaborations

Michael Sokolov 7 collaborations

James Angelo 5 collaborations

Xuankuo Xu 5 collaborations

Sanchayita Ghose 5 collaborations

Nicole Ulmer 5 collaborations

Harini Narayanan 5 collaborations

Thomas Müller-Späth 5 collaborations

Chiara De Luca 4 collaborations

Alberto Cavazzini 4 collaborations

Martina Catani 4 collaborations

Fabian Feidl 4 collaborations

João Medeiros Garcia Alcântara 4 collaborations

Simona Felletti 3 collaborations

Giulio Lievore 3 collaborations

Zheng Jian Li 3 collaborations

Moritz Wolf 3 collaborations

Jean-Marc Bielser 3 collaborations

Giuseppe Storti 3 collaborations

Martin F Luna 3 collaborations

Marco Macis 2 collaborations

Antonio Ricci 2 collaborations

Walter Cabri 2 collaborations

Ruben Wälchli 2 collaborations

Matevz Podobnik 2 collaborations

Moritz K F Wolf 2 collaborations

Ernesto Scibona 2 collaborations

Francesco Iannacci 2 collaborations

Nicolò Manfredini 2 collaborations

Davide Moscatelli 2 collaborations

Tatiana Chenet 2 collaborations

Richard Weldon 2 collaborations

Tae Keun Kim 2 collaborations

Ismaele Fioretti 2 collaborations

Alessandro Buratti 1 collaboration

Mariana Ressurreição 1 collaboration

Xavier Le Saoût 1 collaboration

Caterina Ruggeri 1 collaboration

Aurélie Closet 1 collaboration

Monika Bzowska 1 collaboration

Vania Bertrand 1 collaboration

Daniel J Karst 1 collaboration

Alessia Bachmann 1 collaboration

Katia Cantalupo 1 collaboration

Miroslav Soos 1 collaboration

Marcel Lorenz 1 collaboration

Carolina Paganini 1 collaboration

Loïc Chappuis 1 collaboration

Yashi Xiao 1 collaboration

Arianna Zanoni 1 collaboration

Ce Shi 1 collaboration

Dong-Qiang Lin 1 collaboration

Stefano Caimi 1 collaboration

Claudio Colombo 1 collaboration

Raffaele Ferrari 1 collaboration

Moritz von Stosch 1 collaboration

Mariano Nicolas Cruz Bournazou 1 collaboration

Gianmarco Polotti 1 collaboration

Jakub Domaradzki 1 collaboration

Daniel Baur 1 collaboration

Srinivas Chollangi 1 collaboration

Tobias Seidler 1 collaboration

Martin Francisco Luna 1 collaboration

Luisa Pasti 1 collaboration

Joanna Hajduk 1 collaboration

Robert Steinhoff 1 collaboration

Daniel Karst 1 collaboration

Renato Zenobi 1 collaboration

Daniela Perrone 1 collaboration

Elena Marchesi 1 collaboration

Abdallah Ayub Bham 1 collaboration

Philipp Zürcher 1 collaboration

David Brühlmann 1 collaboration

Raphael Ducommun 1 collaboration

Matthieu Stettler 1 collaboration

Martin Jordan 1 collaboration

Kevin Potter 1 collaboration

Elenore Wiggin 1 collaboration

Dragana Ristanovic 1 collaboration

Andrea Müller 1 collaboration

Benedetta Sechi 1 collaboration

Juan Jose Romero Conde 1 collaboration

Simone Garbellini 1 collaboration

Francesco Distante 1 collaboration

Felix Pfeifer 1 collaboration

Lars Behle 1 collaboration

Gonzalo Guillén-Gosálbez 1 collaboration

Martina Marani 1 collaboration

Paolo Camesasca 1 collaboration

Michele Chen 1 collaboration

Fani Sousa 1 collaboration