BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant.
in-silico modeling
Imidazoquinoline
TLR7
TLR8
adjuvant
imiquimod
influenza
vaccine
Journal
Human vaccines & immunotherapeutics
ISSN: 2164-554X
Titre abrégé: Hum Vaccin Immunother
Pays: United States
ID NLM: 101572652
Informations de publication
Date de publication:
02 08 2020
02 08 2020
Historique:
pubmed:
17
4
2020
medline:
22
6
2021
entrez:
17
4
2020
Statut:
ppublish
Résumé
Better adjuvants are needed for vaccines against seasonal influenza. TLR7 agonists are potent activators of innate immune responses and thereby may be promising adjuvants. Among the imidazoquinoline compounds, 1-benzyl-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (BBIQ) was reported to be a highly active TLR7 agonist but has remained relatively unexplored because of its commercial unavailability. Indeed,
Identifiants
pubmed: 32298200
doi: 10.1080/21645515.2019.1710409
pmc: PMC7482670
doi:
Substances chimiques
Adjuvants, Immunologic
0
Influenza Vaccines
0
Toll-Like Receptor 7
0
Imiquimod
P1QW714R7M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1989-1996Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201400053C
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201800044C
Pays : United States
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