Cardio-Renal Biomarker Soluble Urokinase-Type Plasminogen Activator Receptor Is Associated With Cardiovascular Death and Myocardial Infarction in Patients With Coronary Artery Disease Independent of Troponin, C-Reactive Protein, and Renal Function.
Aged
Biomarkers
/ blood
C-Reactive Protein
/ analysis
Coronary Artery Disease
/ blood
Female
Germany
/ epidemiology
Glomerular Filtration Rate
Heart Disease Risk Factors
Humans
Kidney
/ physiopathology
Kidney Diseases
/ diagnosis
Male
Middle Aged
Myocardial Infarction
/ blood
Predictive Value of Tests
Prognosis
Receptors, Urokinase Plasminogen Activator
/ blood
Risk Assessment
Time Factors
Troponin
/ blood
biomarker
coronary artery disease
prognosis
soluble urokinase‐type plasminogen activator receptor
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
21 04 2020
21 04 2020
Historique:
pubmed:
18
4
2020
medline:
9
3
2021
entrez:
18
4
2020
Statut:
ppublish
Résumé
Background Risk stratification among patients with coronary artery disease (CAD) is of considerable interest due to the potential to guide secondary preventive therapies. Thus, we evaluated the predictive value of soluble urokinase-type plasminogen activator receptor (suPAR) levels for cardiovascular mortality and nonfatal myocardial infarction in patients with CAD. Methods and Results Plasma levels of suPAR were measured in a cohort of 1703 patients with documented CAD as evidenced by coronary angiography-including 626 patients with acute coronary syndrome and 1077 patients with stable angina pectoris. Cardiovascular death and/or nonfatal myocardial infarction were defined as main outcome measures. During a median follow-up of 3.5 years, suPAR levels reliably predicted cardiovascular death or myocardial infarction in CAD, evidenced by survival curves stratified for tertiles of suPAR levels. In Cox regression analyses, the hazard ratio for the prediction of cardiovascular death and/or myocardial infarction was 2.19 (
Identifiants
pubmed: 32299288
doi: 10.1161/JAHA.119.015452
pmc: PMC7428542
doi:
Substances chimiques
Biomarkers
0
PLAUR protein, human
0
Receptors, Urokinase Plasminogen Activator
0
Troponin
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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