Advanced multiparametric magnetic resonance imaging of multinodular and vacuolating neuronal tumor.
diagnosis
diagnostic imaging
magnetic resonance imaging
multinodular and vacuolating neuronal tumor
neoplasms
Journal
European journal of neurology
ISSN: 1468-1331
Titre abrégé: Eur J Neurol
Pays: England
ID NLM: 9506311
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
23
01
2020
accepted:
10
04
2020
pubmed:
18
4
2020
medline:
22
6
2021
entrez:
18
4
2020
Statut:
ppublish
Résumé
Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a rare brain lesion with suggestive imaging features. The aim of our study was to report the largest series of MVNTs so far and to evaluate the utility of advanced multiparametric magnetic resonance (MR) techniques. This multicenter retrospective study was approved by our institutional research ethics board. From July 2014 to May 2019, two radiologists read in consensus the MR examinations of patients presenting with a lesion suggestive of an MVNT. They analyzed the lesions' MR characteristics on structural images and advanced multiparametric MR imaging. A total of 64 patients (29 women and 35 men, mean age 44.2 ± 15.1 years) from 25 centers were included. Lesions were all hyperintense on fluid-attenuated inversion recovery and T2-weighted imaging without post-contrast enhancement. The median relative apparent diffusion coefficient on diffusion-weighted imaging was 1.13 [interquartile range (IQR), 0.2]. Perfusion-weighted imaging showed no increase in perfusion, with a relative cerebral blood volume of 1.02 (IQR, 0.05) and a relative cerebral blood flow of 1.01 (IQR, 0.08). MR spectroscopy showed no abnormal peaks. Median follow-up was 2 (IQR, 1.2) years, without any changes in size. A comprehensive characterization protocol including advanced multiparametric magnetic resonance imaging sequences showed no imaging patterns suggestive of malignancy in MVNTs. It might be useful to better characterize MVNTs.
Sections du résumé
BACKGROUND AND PURPOSE
Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a rare brain lesion with suggestive imaging features. The aim of our study was to report the largest series of MVNTs so far and to evaluate the utility of advanced multiparametric magnetic resonance (MR) techniques.
METHODS
This multicenter retrospective study was approved by our institutional research ethics board. From July 2014 to May 2019, two radiologists read in consensus the MR examinations of patients presenting with a lesion suggestive of an MVNT. They analyzed the lesions' MR characteristics on structural images and advanced multiparametric MR imaging.
RESULTS
A total of 64 patients (29 women and 35 men, mean age 44.2 ± 15.1 years) from 25 centers were included. Lesions were all hyperintense on fluid-attenuated inversion recovery and T2-weighted imaging without post-contrast enhancement. The median relative apparent diffusion coefficient on diffusion-weighted imaging was 1.13 [interquartile range (IQR), 0.2]. Perfusion-weighted imaging showed no increase in perfusion, with a relative cerebral blood volume of 1.02 (IQR, 0.05) and a relative cerebral blood flow of 1.01 (IQR, 0.08). MR spectroscopy showed no abnormal peaks. Median follow-up was 2 (IQR, 1.2) years, without any changes in size.
CONCLUSIONS
A comprehensive characterization protocol including advanced multiparametric magnetic resonance imaging sequences showed no imaging patterns suggestive of malignancy in MVNTs. It might be useful to better characterize MVNTs.
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1561-1569Informations de copyright
© 2020 European Academy of Neurology.
Références
Huse JT, Edgar M, Halliday J, Mikolaenko I, Lavi E, Rosenblum MK. Multinodular and vacuolating neuronal tumors of the cerebrum: 10 cases of a distinctive seizure-associated lesion: multinodular and vacuolating neuronal tumors. Brain Pathol 2013; 23: 515-524.
Louis DN, Perry A, Reifenberger G, et al. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol (Berl) 2016; 131: 803-820.
Nunes RH, Hsu CC, da Rocha AJ, et al. Multinodular and vacuolating neuronal tumor of the cerebrum: a new, “Leave Me Alone” lesion with a characteristic imaging pattern. Am J Neuroradiol 2017; 38: 1899-1904.
Alsufayan R, Alcaide-Leon P, de Tilly LN, Mandell DM, Krings T. Natural history of lesions with the MR imaging appearance of multinodular and vacuolating neuronal tumor. Neuroradiology 2017; 59: 873-883.
Badat N, Savatovsky J, Charbonneau F, Collin A, Lecler A. Multinodular vacuolating and neuronal tumor of the cerebrum. Neurology 2017; 89: 304-305.
Shitara S, Tokime T, Akiyama Y. Multinodular and vacuolating neuronal tumor: a case report and literature review. Surg Neurol Int 2018; 9: 63.
Gonzalez-Quarante LH, Ruiz-Juretschke F, Sola Vendrell E, et al. Multinodular and vacuolating neuronal tumor of the cerebrum. A rare entity. New case and review of the literature. Neurocirugía 2018; 29: 44-55.
Makrakis D, Veneris S, Papadaki E. Multinodular and vacuolating neuronal tumor incidentally discovered in a young man: conventional and advanced MRI features. Radiol Case Rep 2018; 13: 960-964.
Fukushima S, Yoshida A, Narita Y, et al. Multinodular and vacuolating neuronal tumor of the cerebrum. Brain Tumor Pathol 2015; 32: 131-136.
Monté A-SMC, D’Arco F, De Cocker LJL. Multinodular and vacuolating neuronal tumor in an adolescent with Klinefelter syndrome. Neuroradiology 2017; 59: 1187-1188.
Johnson DR, Guerin JB, Giannini C, Morris JM, Eckel LJ, Kaufmann TJ. 2016 updates to the WHO brain tumor classification system: what the radiologist needs to know. Radiographics 2017; 37: 2164-2180.
Lecler A, Bailleux J, Carsin B, et al. Multinodular and vacuolating posterior fossa lesions of unknown significance. AJNR Am J Neuroradiol 2019; 40: 1689-1684.
Lecler A, Chauvet D, Biassette HA, Savatovsky J. Multiparametric imaging improves confidence in the diagnosis of multinodular and vacuolating neuronal tumor of the cerebrum. AJNR Am J Neuroradiol 2018; 39: E32-E33.
Choi E, Kim S-I, Won J-K, et al. Clinicopathological and molecular analysis of multinodular and vacuolating neuronal tumors of the cerebrum. Hum Pathol 2018; 86: 203-212.
Calderon-Garcidueñas AL, Mathon B, Lévy P, et al. New clinicopathological associations and histoprognostic markers in ILAE types of hippocampal sclerosis. Brain Pathol Zurich Switz 2018; 28: 644-655.
Thom M, Liu J, Bongaarts A, et al. Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia?: MNVT: dysplasia or neoplasia. Brain Pathol 2018; 28: 155-171.
Yamaguchi M, Komori T, Nakata Y, Yagishita A, Morino M, Isozaki E. Multinodular and vacuolating neuronal tumor affecting amygdala and hippocampus: a quasi-tumor? Pathol Int 2016; 66: 34-41.
Cathcart SJ, Klug JR, Helvey JT, L. White M, Gard AP, McComb RD. Multinodular and vacuolating neuronal tumor: a rare seizure-associated entity. Am J Surg Pathol 2017; 41: 1005-1010.
Gökçe E. Magnetic resonance imaging findings of two cases with multinodular and vacuolating neuronal tumor. Acta Neurol Belg 2017; 120: 457-461.
Nagaishi M, Yokoo H, Nobusawa S, et al. Localized overexpression of alpha-internexin within nodules in multinodular and vacuolating neuronal tumors: Expression of alpha-internexin in MVNT. Neuropathology 2015; 35: 561-568.
Lecler A, Balvay D, Cuenod C-A, et al. Quality-based pharmacokinetic model selection on DCE-MRI for characterizing orbital lesions. J Magn Reson Imaging JMRI 2019; 50: 1514-1525.
Baščarević V, Pejović AT, Ristić AJ, et al. Multinodular and vacuolating neuronal tumour of the cerebrum: a rare neuroimaging incidentaloma or a potentially treatable cause of focal epilepsy? Epileptic Disord 2019; 21: 209-214.
Galletto Pregliasco A, Collin A, Guéguen A, et al. Improved detection of new MS lesions during follow-up using an automated MR coregistration-fusion method. AJNR Am J Neuroradiol 2018; 39: 1226-1232.