Epigenetic Therapy for Epithelioid Sarcoma.

Benzamides / therapeutic use Biphenyl Compounds Cell Line, Tumor Chromatin Assembly and Disassembly DNA Helicases / metabolism Enhancer of Zeste Homolog 2 Protein / drug effects Enzyme Inhibitors / pharmacology Epigenesis, Genetic / genetics Epigenomics Genetic Therapy / methods Humans Morpholines Nuclear Proteins / metabolism Pyridones / therapeutic use Sarcoma / drug therapy Transcription Factors / metabolism

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
16 04 2020
Historique:
entrez: 18 4 2020
pubmed: 18 4 2020
medline: 24 11 2020
Statut: ppublish

Résumé

Tazemetostat is the first epigenetic therapy to gain FDA approval in a solid tumor. This lysine methyltransferase inhibitor targets EZH2, the enzymatic subunit of the PRC2 transcriptional silencing complex. Tumors with mutations in subunits of the SWI/SNF chromatin remodeling complex, inclusive of most epithelioid sarcomas, are sensitive to EZH2 inhibition.

Identifiants

DOI: 10.1016/j.cell.2020.03.042 PMID: 32302562
pubmed: 32302562
pii: S0092-8674(20)30335-4
doi: 10.1016/j.cell.2020.03.042
pii:
doi:

Substances chimiques

Benzamides 0
Biphenyl Compounds 0
Enzyme Inhibitors 0
Morpholines 0
Nuclear Proteins 0
Pyridones 0
Transcription Factors 0
EZH2 protein, human EC 2.1.1.43
Enhancer of Zeste Homolog 2 Protein EC 2.1.1.43
DNA Helicases EC 3.6.4.-
tazemetostat Q40W93WPE1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

211

Informations de copyright

Copyright © 2020. Published by Elsevier Inc.

Auteurs

Scott B Rothbart (SB)

Center for Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: scott.rothbart@vai.org.

Stephen B Baylin (SB)

Center for Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. Electronic address: sbaylin@jhmi.edu.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Benzamides › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Dérivés du biphényle › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Assemblage et désassemblage de la chromatine › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Helicase › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Protéines du groupe Polycomb › Complexe répresseur Polycomb-2 › Protéine-2 homologue de l'activateur de Zeste › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Thérapie génétique › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Oxazines › Morpholines › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Pyridones › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Sarcomes › Epigenetic Therapy for Epithelioid Sarcoma.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Epigenetic Therapy for Epithelioid Sarcoma.