Solid organ donation after death from listeria encephalitis: A case report.
bacteremia
donor
invasive listeriosis
kidney transplantation
listeria monocytogenes
liver transplantation
meningitis
organ procurement
sepsis
solid organ transplantation
Journal
Transplant infectious disease : an official journal of the Transplantation Society
ISSN: 1399-3062
Titre abrégé: Transpl Infect Dis
Pays: Denmark
ID NLM: 100883688
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
26
02
2020
revised:
06
04
2020
accepted:
12
04
2020
pubmed:
18
4
2020
medline:
4
2
2021
entrez:
18
4
2020
Statut:
ppublish
Résumé
Despite organ shortage, organs from donors with listeria infections have been discarded for transplantation. We present the first-reported case of liver transplantation following listeria encephalitis. The patient was admitted with progressing neurological symptoms after an episode of gastroenteritis. Rhombo-encephalitis was diagnosed, and Listeria monocytogenes was found to be the causative pathogen. Despite proper antibiotic treatment and rapid clearance of bacteremia, he continued to deteriorate and became brain dead, after which organ donation was performed. At procurement, he had been treated with amoxicillin for 9 days. The recipient was treated with pipercillin/tazobactam for 21 days. Besides an anastomotic biliary stricture, necessitating endoscopic dilatation and stenting, further clinical course was uneventful and she is doing well eleven months post-transplant. Our case suggests that listeria encephalitis is not an absolute contra-indication to solid organ donation. We suggest that donors should be treated with adequate antibiotics for at least 48h prior to procurement and advocate confirmation of sterile blood cultures as a prerequisite for donation. According to listeriosis guidelines, we suggest that the recipient should be treated with targeted antibiotics for at least 2 weeks. The risk of transmission should, however, always be balanced carefully against the suspected waiting list mortality.
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13295Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Ison MG, Grossi P. & the AST Infectious Diseases Community of Practice. Donor-derived infections in solid organ transplantation. Am J Transplant. 2013;13:22-30.
Issa NC et al Potential for Expansion of the Donor Pool The use of liver grafts from donors with bacterial Abstract Unavailable. Liver Transplant. 2002;8:977-979.
European Committee on Organ transplantation. Bacterial sepsis, -meningitis, -endocarditis and -osteomyelitis. in Guide to the quality and safety of organs for transplantation (ed. EDQM) (2018).
Hristea I, Bunnapradist S, Peng A, Puliyanda D, Vo A, Jordan SC. The onset of rapidly progressive neurologic deterioration after a brief gastrointestinal illness in a renal allograft recipient. Transpl Infect Dis. 2007;9:142-147.
van Veen KEB, Brouwer MC, van der Ende A, van de Beek D. Bacterial meningitis in solid organ transplant recipients: a population-based prospective study. Transpl Infect Dis. 2016;18:674-680.
Choudhury N, Khan AB, Tzvetanov I et al Cerebellar abscess caused by Listeria monocytogenes in a liver transplant patient. Transpl Infect Dis. 2013;15:224-228.
Piette E, Vandermeulen M, Meurisse N et al listeriosis after liver transplantation: report of two cases. Transpl Infect Dis. 2019;21(4):e13122.
Swaminathan B, Gerner-Smidt P. The epidemiology of human listeriosis. Microbes Infect. 2007;9:1236-1243.
Fernàndez-Sabé N, Cervera C, López-Medrano F et al Risk factors, clinical features, and outcomes of listeriosis in solid-organ transplant recipients: a matched case-control study. Clin Infect Dis. 2009;49:1153-1159.
Thønnings S, Knudsen JD, Schønheyder HC et al Antibiotic treatment and mortality in patients with Listeria monocytogenes meningitis or bacteraemia. Clin Microbiol Infect. 2016;22:725-730.
Schlech WF. Epidemiology and Clinical Manifestations of Listeria monocytogenes Infection. Microbiol Spectr. 2019;7:3-14.
De Noordhout CM, Devleesschauwer B, Angulo FJ et al The global burden of listeriosis: a systematic review and meta- analysis. Lancet Infect Dis. 2015;14:1073-1082.
Pohl AM, Pouillot R, Bazaco MC et al Differences among Incidence Rates of Invasive Listeriosis in the U.S. FoodNet Population by Age, Sex, Race/Ethnicity, and Pregnancy Status, 2008-2016. Foodborne Pathog Dis. 2019;16:290-297.
EFSA (European Food Safety Authority) and ECDC (European Centre for Disease Prevention and Control). The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2016. EFSA Journal 15, (2017).
Temple ME, Nahata MC. Treatment of Listeriosis. Ann Pharmacother. 2000;34:656-661.
Jones E, MacGowan A. Antimicrobial chemotherapy in human infection due to Listeria Monocytogenes. Eur J Clin Microbiol Infect Dis. 1995;14:165-175.
Dickstein Y, Oster Y, Shimon O et al Antibiotic treatment for invasive nonpregnancy-associated listeriosis and mortality: a retrospective cohort study. Eur J Clin Microbiol Infect Dis. 2019;38:2243-2251.
Baldassarre JS, Ingerman MJ, Nansteel J, Santoro J. Development of listeria meningitis during vancomycin therapy: a case report. J Chem Inf Model. 1991;164:221-222.
Viale P, Furlanut M, Cristini F, Cadeo B, Pavan F, Pea F. Major role of levofloxacin in the treatment of a case of Listeria monocytogenes meningitis. Diagn Microbiol Infect Dis. 2007;58:137-139.
Ruiz-Bolivar Z, Neuque-Rico MC, Poutou-Piñales RA, Carrascal-Camacho AK, Mattar S. Antimicrobial susceptibility of listeria monocytogenes food isolates from different cities in Colombia. Foodborne Pathog. Dis. 2011;8:913-919.
Kovacevic J, Sagert J, Wozniak A, Gilmour MW, Allen KJ. Antimicrobial resistance and co-selection phenomenon in Listeria spp. recovered from food and food production environments. Food Microbiol. 2013;34:319-327.
Madeo M, Musumeci R, Careddu AM, Amato E, Pontello MM, Cocuzza CE. Antimicrobial susceptibility of Listeria monocytogenes isolates from human cases in northern Italy, 2008-2010: MIC determination according to EUCAST broth microdilution method. J. Chemother. 2014;27:201-206.
EUCAST. Clinical breakpoints for Listeria monocytogenes. (2011).
Limaye AP, Perkins JD, Kowdley KV. Listeria infection after liver transplantation: Report of a case and review of the literature. Am J Gastroenterol. 1998;93:1942-1944.
Vazquez-Boland JA, Kuhn M, Berche P et al Listeria pathogenesis and molecular virulence determinants. Clin Microbiol Rev. 2001;14:584-640.