Tumor Cell-Derived Angiopoietin-2 Promotes Metastasis in Melanoma.
Angiopoietin-2
/ genetics
Animals
Autocrine Communication
Biopsy
Cell Line, Tumor
Disease Models, Animal
Disease Progression
Female
Gene Expression Profiling
Gene Knockdown Techniques
Human Umbilical Vein Endothelial Cells
Humans
Kaplan-Meier Estimate
MAP Kinase Signaling System
Melanoma
/ mortality
Mice
Nevus
/ pathology
Reactive Oxygen Species
/ metabolism
Skin
/ pathology
Skin Neoplasms
/ mortality
Tissue Array Analysis
Tumor Microenvironment
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 06 2020
15 06 2020
Historique:
received:
05
09
2019
revised:
16
03
2020
accepted:
14
04
2020
pubmed:
19
4
2020
medline:
11
11
2020
entrez:
19
4
2020
Statut:
ppublish
Résumé
The angiopoietin (Angpt)-TIE signaling pathway controls vascular maturation and maintains the quiescent phenotype of resting vasculature. The contextual agonistic and antagonistic Tie2 ligand ANGPT2 is believed to be exclusively produced by endothelial cells, disrupting constitutive ANGPT1-TIE2 signaling to destabilize the microvasculature during pathologic disorders like inflammation and cancer. However, scattered reports have also portrayed tumor cells as a source of ANGPT2. Employing ISH-based detection of
Identifiants
pubmed: 32303578
pii: 0008-5472.CAN-19-2660
doi: 10.1158/0008-5472.CAN-19-2660
pmc: PMC7611175
mid: EMS128771
doi:
Substances chimiques
ANGPT2 protein, human
0
Angiopoietin-2
0
Angpt2 protein, mouse
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2586-2598Subventions
Organisme : European Research Council
ID : 787181
Pays : International
Informations de copyright
©2020 American Association for Cancer Research.
Références
Oncol Rep. 2006 Apr;15(4):779-83
pubmed: 16525658
Physiology (Bethesda). 2011 Jun;26(3):192-205
pubmed: 21670165
Cancer Cell. 2014 Dec 8;26(6):880-895
pubmed: 25490450
Nat Rev Drug Discov. 2017 Sep;16(9):635-661
pubmed: 28529319
Clin Cancer Res. 2009 Feb 15;15(4):1384-92
pubmed: 19228739
Cancer Lett. 2013 Sep 1;337(2):276-84
pubmed: 23643942
Oncogenesis. 2018 Jan 24;7(1):10
pubmed: 29362402
Redox Biol. 2017 Aug;12:208-215
pubmed: 28259101
EMBO J. 1991 Nov;10(11):3167-75
pubmed: 1915289
Exp Dermatol. 2015 Jun;24(6):424-9
pubmed: 25776770
Nat Commun. 2019 Jun 12;10(1):2576
pubmed: 31189900
Nat Rev Cancer. 2017 Aug;17(8):457-474
pubmed: 28706266
Oxid Med Cell Longev. 2016;2016:4350965
pubmed: 26998193
Lancet. 2018 Sep 15;392(10151):971-984
pubmed: 30238891
Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8904-9
pubmed: 12861074
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Mol Biol Cell. 2015 Nov 5;26(22):3932-9
pubmed: 26543202
Cancer Cell. 2004 Nov;6(5):507-16
pubmed: 15542434
Clin Cancer Res. 2018 Mar 15;24(6):1260-1270
pubmed: 29127120
Leuk Res. 2010 Mar;34(3):312-21
pubmed: 19616847
Int J Cancer. 2003 Feb 10;103(4):466-74
pubmed: 12478661
FASEB J. 2011 Oct;25(10):3325-35
pubmed: 21685330
Sci Transl Med. 2017 Apr 12;9(385):
pubmed: 28404865
Trends Biochem Sci. 2016 Mar;41(3):261-273
pubmed: 26857402
Nat Rev Mol Cell Biol. 2009 Mar;10(3):165-77
pubmed: 19234476
Cancer Res. 2009 Feb 15;69(4):1324-33
pubmed: 19208839
Blood. 2004 Jun 1;103(11):4150-6
pubmed: 14976056
Cell Mol Life Sci. 2016 Sep;73(17):3221-47
pubmed: 27100828
Stem Cells Int. 2019 Apr 7;2019:9757201
pubmed: 31089338
Cancer Res. 2007 May 1;67(9):4254-63
pubmed: 17483337
Nat Rev Dis Primers. 2015 Apr 23;1:15003
pubmed: 27188223
Cell Rep. 2014 Aug 7;8(3):696-706
pubmed: 25088418