Cystathionine gamma-lyase/H
Acetyl Coenzyme A
/ metabolism
Animals
Cystathionine gamma-Lyase
/ genetics
Disease Models, Animal
Fatty Acids, Nonesterified
/ metabolism
Hep G2 Cells
Humans
Hydrogen Sulfide
/ metabolism
Lipid Metabolism
/ physiology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Non-alcoholic Fatty Liver Disease
/ physiopathology
Acetyl-CoA
Choline deficient diet
Cystathionine gamma-lyase
H(2)S
Lipid metabolism
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
01 Jul 2020
01 Jul 2020
Historique:
received:
20
02
2020
revised:
05
04
2020
accepted:
08
04
2020
pubmed:
20
4
2020
medline:
2
6
2020
entrez:
20
4
2020
Statut:
ppublish
Résumé
Hydrogen sulfide (H Both in vitro cell model and in vivo animal model of lipid accumulation were used in this study. Western blotting and real-time PCR were used for analysis of protein and mRNA expression. Acetyl-CoA was analyzed by a coupled enzyme assay, and lipid accumulation was observed with Oil Red O staining. Incubation of human liver carcinoma (HepG2) cells with a mixture of free fatty acids (FFAs) or high glucose reduced CSE expression and H CSE/H
Identifiants
pubmed: 32305523
pii: S0024-3205(20)30409-4
doi: 10.1016/j.lfs.2020.117661
pii:
doi:
Substances chimiques
Fatty Acids, Nonesterified
0
Acetyl Coenzyme A
72-89-9
Cystathionine gamma-Lyase
EC 4.4.1.1
Hydrogen Sulfide
YY9FVM7NSN
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117661Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest No competing financial interest exists.