Anti-brain protein autoantibodies are detectable in extraparenchymal but not parenchymal neurocysticercosis.
Anti-brain autoantibodies
Autoantigens
Extraparenchymal
HP-10
Neurocysticercosis
Parenchymal
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 07 2020
15 07 2020
Historique:
received:
14
01
2020
revised:
02
04
2020
accepted:
04
04
2020
pubmed:
20
4
2020
medline:
12
11
2020
entrez:
20
4
2020
Statut:
ppublish
Résumé
Neurocysticercosis (NC) presents a spectrum of clinical manifestations, with two broad clinical entities based on the central nervous system location of the parasite: extraparenchymal (EP-NC) and parenchymal (P-NC). In this work, using quantitative immunoblot methodology, we demonstrate the presence of autoantibodies to brain proteins in CSF from EP-NC, but not P-NC, patients. There was striking correlation between the level of autoantibodies and the levels of the secreted metacestode glycoprotein HP-10, suggesting that the level of stimulation of the autoantibody response may be a function of the number of viable parasites. Nine corresponding proteins autoantigens were provisionally identified by mass spectroscopy.
Identifiants
pubmed: 32305783
pii: S0165-5728(20)30026-6
doi: 10.1016/j.jneuroim.2020.577234
pii:
doi:
Substances chimiques
Autoantibodies
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577234Subventions
Organisme : Wellcome Trust
ID : 208402/Z/17/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.