Neurochemical and Ultrastructural Characterization of Unmyelinated Non-peptidergic C-Nociceptors and C-Low Threshold Mechanoreceptors Projecting to Lamina II of the Mouse Spinal Cord.

Animals Calcitonin Gene-Related Peptide / metabolism Cytokines / metabolism Ganglia, Spinal / metabolism Intracellular Signaling Peptides and Proteins / metabolism Male Mechanoreceptors / ultrastructure Mice, Transgenic Myelin Sheath / ultrastructure Nociceptors / ultrastructure Peptides / metabolism Plant Lectins / metabolism Sensory Receptor Cells / metabolism Spinal Cord / metabolism Spinal Cord Dorsal Horn / metabolism TRPV Cation Channels / metabolism
C-LTMRs GINIP IB4 Non-peptidergic C-Ncs TAFA4 TRPV1

Journal

Cellular and molecular neurobiology
ISSN: 1573-6830
Titre abrégé: Cell Mol Neurobiol
Pays: United States
ID NLM: 8200709

Informations de publication

Date de publication:
Mar 2021
Historique:
received: 14 02 2020
accepted: 09 04 2020
pubmed: 20 4 2020
medline: 4 9 2021
entrez: 20 4 2020
Statut: ppublish

Résumé

C-nociceptors (C-Ncs) and non-nociceptive C-low threshold mechanoreceptors (C-LTMRs) are two subpopulations of small unmyelinated non-peptidergic C-type neurons of the dorsal root ganglia (DRGs) with central projections displaying a specific pattern of termination in the spinal cord dorsal horn. Although these two subpopulations exist in several animals, remarkable neurochemical differences occur between mammals, particularly rat/humans from one side and mouse from the other. Mouse is widely investigated by transcriptomics. Therefore, we here studied the immunocytochemistry of murine C-type DRG neurons and their central terminals in spinal lamina II at light and electron microscopic levels. We used a panel of markers for peptidergic (CGRP), non-peptidergic (IB4), nociceptive (TRPV1), non-nociceptive (VGLUT3) C-type neurons and two strains of transgenic mice: the TAFA4

Identifiants

DOI: 10.1007/s10571-020-00847-w PMID: 32306148
pubmed: 32306148
doi: 10.1007/s10571-020-00847-w
pii: 10.1007/s10571-020-00847-w
doi:

Substances chimiques

Cytokines 0
Griffonia simplicifolia lectins 0
Intracellular Signaling Peptides and Proteins 0
Peptides 0
Plant Lectins 0
TAFA4 protein, mouse 0
TRPV Cation Channels 0
TRPV1 protein, mouse 0
Calcitonin Gene-Related Peptide JHB2QIZ69Z

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

247-262

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doi: 10.1007/s10620-011-1970-x pubmed: 22160634

Auteurs

Chiara Salio (C)

Department of Veterinary Sciences, University of Turin, 10095, Grugliasco, Italy.
ORCID: 0000-0002-4956-3563

Patrizia Aimar (P)

Department of Veterinary Sciences, University of Turin, 10095, Grugliasco, Italy.

Pascale Malapert (P)

Aix-Marseille-Université, CNRS, Institut de Biologie du Développement de Marseille, UMR 7288, case 907, 13288, Marseille Cedex 09, France.

Aziz Moqrich (A)

Aix-Marseille-Université, CNRS, Institut de Biologie du Développement de Marseille, UMR 7288, case 907, 13288, Marseille Cedex 09, France.

Adalberto Merighi (A)

Department of Veterinary Sciences, University of Turin, 10095, Grugliasco, Italy. adalberto.merighi@unito.it.
ORCID: 0000-0002-1140-3556

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Neurochemical and Ultrastructural...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Peptide relié au gène de la calcitonine › Neurochemical and Ultrastructural...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Neurochemical and Ultrastructural...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs spinaux › Racines des nerfs spinaux › Ganglions sensitifs des nerfs spinaux › Neurochemical and Ultrastructural...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Neurochemical and Ultrastructural...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Mécanorécepteurs › Neurochemical and Ultrastructural...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Neurochemical and Ultrastructural...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Gaine de myéline › Neurochemical and Ultrastructural...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Nocicepteurs › Neurochemical and Ultrastructural...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Neurochemical and Ultrastructural...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Lectines végétales › Neurochemical and Ultrastructural...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Neurochemical and Ultrastructural...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Neurochemical and Ultrastructural...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Corne dorsale de la moelle spinale › Neurochemical and Ultrastructural...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › Neurochemical and Ultrastructural...