Eicosapentaenoic Acid-Enriched Phosphoethanolamine Plasmalogens Alleviated Atherosclerosis by Remodeling Gut Microbiota to Regulate Bile Acid Metabolism in LDLR
Animals
Atherosclerosis
/ drug therapy
Bile Acids and Salts
/ metabolism
Cholesterol 7-alpha-Hydroxylase
/ genetics
Eicosapentaenoic Acid
/ administration & dosage
Ethanolamines
/ administration & dosage
Gastrointestinal Microbiome
/ drug effects
Humans
Male
Mice
Mice, Knockout
Plasmalogens
/ administration & dosage
Receptors, LDL
/ genetics
atherosclerosis
bile acid
cholesterol metabolism
hyperlipemia
plasmalogen
Journal
Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755
Informations de publication
Date de publication:
13 May 2020
13 May 2020
Historique:
pubmed:
21
4
2020
medline:
2
1
2021
entrez:
21
4
2020
Statut:
ppublish
Résumé
Eicosapentaenoic acid (EPA)-enriched phosphoethanolamine plasmalogens (EPA-PlsEtns) might be retained in the intestine rich in gut microbiota for a long time after treatment. It reminded us that EPA-PlsEtns might affect intestinal microbiota composition and its metabolites, which have been identified as a contributing factor in the development of cardiovascular diseases. In the present study, EPA-PlsEtn administration for 8 weeks significantly reduced the atherosclerotic lesion area in low-density lipoprotein receptor deficient (LDLR
Identifiants
pubmed: 32306729
doi: 10.1021/acs.jafc.9b08296
doi:
Substances chimiques
Bile Acids and Salts
0
Ethanolamines
0
Plasmalogens
0
Receptors, LDL
0
phosphorylethanolamine
78A2BX7AEU
Eicosapentaenoic Acid
AAN7QOV9EA
Cholesterol 7-alpha-Hydroxylase
EC 1.14.14.23
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM