Local anesthesia enhanced with increasing high-frequency ultrasound intensity.
Acoustic intensity
Drug delivery
Insonation
Peripheral nerve
Tetrodotoxin
Journal
Drug delivery and translational research
ISSN: 2190-3948
Titre abrégé: Drug Deliv Transl Res
Pays: United States
ID NLM: 101540061
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
21
4
2020
medline:
3
11
2021
entrez:
21
4
2020
Statut:
ppublish
Résumé
The effect of local anesthetics, particularly those which are hydrophilic, such as tetrodotoxin, is impeded by tissue barriers that restrict access to individual nerve cells. Methods of enhancing penetration of tetrodotoxin into nerve include co-administration with chemical permeation enhancers, nanoencapsulation, and insonation with very low acoustic intensity ultrasound and microbubbles. In this study, we examined the effect of acoustic intensity on nerve block by tetrodotoxin and compared it to the effect on nerve block by bupivacaine, a more hydrophobic local anesthetic. Anesthetics were applied in peripheral nerve blockade in adult Sprague-Dawley rats. Insonation with 1-MHz ultrasound at acoustic intensity greater than 0.5 W/cm
Identifiants
pubmed: 32307675
doi: 10.1007/s13346-020-00760-1
pii: 10.1007/s13346-020-00760-1
pmc: PMC7483597
mid: NIHMS1585978
doi:
Substances chimiques
Anesthetics, Local
0
Bupivacaine
Y8335394RO
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1507-1516Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM131728
Pays : United States
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