Artificial Iron Proteins: Modeling the Active Sites in Non-Heme Dioxygenases.

Binding Sites Dioxygenases / chemistry Ferric Compounds / chemistry Ligands Molecular Conformation Nonheme Iron Proteins / chemistry

Journal

Inorganic chemistry
ISSN: 1520-510X
Titre abrégé: Inorg Chem
Pays: United States
ID NLM: 0366543

Informations de publication

Date de publication:
04 May 2020
Historique:
pubmed: 21 4 2020
medline: 25 11 2020
entrez: 21 4 2020
Statut: ppublish

Résumé

An important class of non-heme dioxygenases contains a conserved Fe binding site that consists of a 2-His-1-carboxylate facial triad. Results from structural biology show that, in the resting state, these proteins are six-coordinate with aqua ligands occupying the remaining three coordination sites. We have utilized biotin-streptavidin (Sav) technology to design new artificial Fe proteins (ArMs) that have many of the same structural features found within active sites of these non-heme dioxygenases. An Sav variant was isolated that contains the S

Identifiants

DOI: 10.1021/acs.inorgchem.9b03791 PMID: 32309932 PMC: PMC7219546
pubmed: 32309932
doi: 10.1021/acs.inorgchem.9b03791
pmc: PMC7219546
mid: NIHMS1584842
doi:

Substances chimiques

Ferric Compounds 0
Ligands 0
Nonheme Iron Proteins 0
Dioxygenases EC 1.13.11.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6000-6009

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM101390
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM120349
Pays : United States
Organisme : NIH HHS
ID : S10 OD023453
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126289
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM110501
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117126
Pays : United States

Références

Inorg Chem. 2011 Apr 4;50(7):2885-96
pubmed: 21381646
J Am Chem Soc. 2012 Dec 5;134(48):19746-57
pubmed: 23167247
Biochemistry. 1996 Aug 20;35(33):10687-701
pubmed: 8718858
Chem Rev. 2000 Jan 12;100(1):235-350
pubmed: 11749238
Nat Chem. 2019 May;11(5):434-441
pubmed: 30778140
Dalton Trans. 2012 May 14;41(18):5662-77
pubmed: 22434362
Acta Crystallogr B Struct Sci Cryst Eng Mater. 2016 Apr;72(Pt 2):171-9
pubmed: 27048719
Curr Opin Struct Biol. 2015 Oct;34:87-98
pubmed: 26342144
Nat Methods. 2014 Jul;11(7):734-6
pubmed: 24813624
Inorg Chem. 2000 Nov 13;39(23):5306-17
pubmed: 11187471
Biochemistry. 2002 Apr 23;41(16):5185-92
pubmed: 11955067
Acc Chem Res. 2016 Sep 20;49(9):1711-21
pubmed: 27529561
J Mol Biol. 2001 Nov 23;314(2):279-91
pubmed: 11718561
Nat Chem Biol. 2009 Dec;5(12):882-4
pubmed: 19915535
Angew Chem Int Ed Engl. 2009;48(31):5580-2
pubmed: 19504506
J Am Chem Soc. 2016 Jul 27;138(29):9073-6
pubmed: 27385206
Nat Commun. 2014 Jul 09;5:4371
pubmed: 25006873
J Biol Inorg Chem. 2005 Mar;10(2):87-93
pubmed: 15739104
J Am Chem Soc. 2004 Nov 10;126(44):14411-8
pubmed: 15521760
Org Lett. 2013 Mar 15;15(6):1406-9
pubmed: 23461621
Chem Rev. 2014 Apr 23;114(8):4366-469
pubmed: 24758379
J Am Chem Soc. 2007 Feb 28;129(8):2275-86
pubmed: 17266307
Methods Enzymol. 2015;563:171-208
pubmed: 26478486
J Am Chem Soc. 2010 Dec 8;132(48):17118-29
pubmed: 21070030
Curr Opin Chem Biol. 2008 Apr;12(2):134-40
pubmed: 18249197
Chem Soc Rev. 2016 Sep 21;45(18):5020-54
pubmed: 27341693
Biochemistry. 2019 Oct 15;58(41):4218-4223
pubmed: 31503454
Crit Rev Biochem Mol Biol. 2004 Jan-Feb;39(1):21-68
pubmed: 15121720
Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7975-8
pubmed: 17096444
J Inorg Biochem. 2006 Sep;100(9):1527-34
pubmed: 16814389
J Am Chem Soc. 2004 Dec 29;126(51):16750-61
pubmed: 15612713
Inorg Chem. 2013 Jul 1;52(13):7394-410
pubmed: 23750826
J Am Chem Soc. 2018 Feb 28;140(8):2739-2742
pubmed: 29401385
Nature. 2015 Jan 1;517(7532):99-103
pubmed: 25470056
Nat Chem. 2010 Dec;2(12):1069-76
pubmed: 21107372
Inorg Chem. 2000 Dec 25;39(26):6086-90
pubmed: 11188526
Chem Soc Rev. 2008 Dec;37(12):2716-44
pubmed: 19020684
J Am Chem Soc. 2017 Dec 6;139(48):17289-17292
pubmed: 29117678
J Am Chem Soc. 2005 Aug 24;127(33):11550-1
pubmed: 16104701
Biochemistry. 2015 Aug 4;54(30):4637-51
pubmed: 26154739
Acc Chem Res. 2011 Jan 18;44(1):47-57
pubmed: 20949947
Nat Chem Biol. 2008 Mar;4(3):186-93
pubmed: 18277980
Nature. 1998 Aug 20;394(6695):805-9
pubmed: 9723623
Chem Rev. 2018 Jan 10;118(1):142-231
pubmed: 28714313
Chem Rev. 2004 Feb;104(2):939-86
pubmed: 14871146
J Biol Inorg Chem. 2017 Apr;22(2-3):339-365
pubmed: 28074299
Inorg Chem. 2003 Nov 3;42(22):7182-8
pubmed: 14577787
Eur J Biochem. 1997 Dec 15;250(3):625-9
pubmed: 9461283

Auteurs

Kelsey R Miller (KR)

Department of Chemistry, 1102 Natural Science II, University of California, Irvine, California 92697, United States.

Jonathan D Paretsky (JD)

Department of Chemistry, 1102 Natural Science II, University of California, Irvine, California 92697, United States.

Alec H Follmer (AH)

Department of Chemistry, 1102 Natural Science II, University of California, Irvine, California 92697, United States.
ORCID: 0000-0002-6244-6804

Tillmann Heinisch (T)

Department of Chemistry, University of Basel, P.O. Box 3350, Mattenstrasse 24a, BPR 1096, CH-4002 Basel, Switzerland.

Kaustuv Mittra (K)

Department of Molecular Biosciences and Biochemistry, University of California, Irvine, California 92697, United States.
ORCID: 0000-0003-2325-1972

Sheraz Gul (S)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

In-Sik Kim (IS)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Franklin D Fuller (FD)

Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.

Alexander Batyuk (A)

Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.

Kyle D Sutherlin (KD)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Aaron S Brewster (AS)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Asmit Bhowmick (A)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Nicholas K Sauter (NK)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Jan Kern (J)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
ORCID: 0000-0002-7272-1603

Junko Yano (J)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
ORCID: 0000-0001-6308-9071

Michael T Green (MT)

Department of Chemistry, 1102 Natural Science II, University of California, Irvine, California 92697, United States.
Department of Molecular Biosciences and Biochemistry, University of California, Irvine, California 92697, United States.
ORCID: 0000-0001-8658-8420

Thomas R Ward (TR)

Department of Chemistry, University of Basel, P.O. Box 3350, Mattenstrasse 24a, BPR 1096, CH-4002 Basel, Switzerland.
ORCID: 0000-0001-8602-5468

A S Borovik (AS)

Department of Chemistry, 1102 Natural Science II, University of California, Irvine, California 92697, United States.
ORCID: 0000-0001-5049-9952

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Artificial Iron Proteins: Modeling the Active...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › Artificial Iron Proteins: Modeling the Active...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du fer › Composés du fer III › Artificial Iron Proteins: Modeling the Active...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Artificial Iron Proteins: Modeling the Active...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Artificial Iron Proteins: Modeling the Active...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Artificial Iron Proteins: Modeling the Active...