Possible Transmission Mechanisms of Mixed Mycobacterium tuberculosis Infection in High HIV Prevalence Country, Botswana.
Botswana
HIV
Mycobacterium tuberculosis
Tuberculosis and other mycobacteria
bacteria
genotyping
mixed infection
tuberculosis
Journal
Emerging infectious diseases
ISSN: 1080-6059
Titre abrégé: Emerg Infect Dis
Pays: United States
ID NLM: 9508155
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
entrez:
21
4
2020
pubmed:
21
4
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
Tuberculosis caused by concurrent infection with multiple Mycobacterium tuberculosis strains (i.e., mixed infection) challenges clinical and epidemiologic paradigms. We explored possible transmission mechanisms of mixed infection in a population-based, molecular epidemiology study in Botswana during 2012-2016. We defined mixed infection as multiple repeats of alleles at >2 loci within a discrete mycobacterial interspersed repetitive unit-variable-number tandem-repeat (MIRU-VNTR) result. We compared mixed infection MIRU-VNTR results with all study MIRU-VNTR results by considering all permutations at each multiple allele locus; matched MIRU-VNTR results were considered evidence of recently acquired strains and nonmatched to any other results were considered evidence of remotely acquired strains. Among 2,051 patients, 34 (1.7%) had mixed infection, of which 23 (68%) had recently and remotely acquired strains. This finding might support the mixed infection mechanism of recent transmission and simultaneous remote reactivation. Further exploration is needed to determine proportions of transmission mechanisms in settings where mixed infections are prevalent.
Identifiants
pubmed: 32310078
doi: 10.3201/eid2605.191638
pmc: PMC7181944
doi:
Substances chimiques
DNA, Bacterial
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
953-960Subventions
Organisme : NIAID NIH HHS
ID : K01 AI118559
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI097045
Pays : United States
Organisme : PEPFAR
Pays : United States
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