Development of a Unique T Cell Receptor Gene-Transferred Tax-Redirected T Cell Immunotherapy for Adult T Cell Leukemia.

Adult Animals Gene Products, tax / genetics Genes, T-Cell Receptor Human T-lymphotropic virus 1 Humans Immunotherapy Leukemia-Lymphoma, Adult T-Cell / therapy Leukocytes, Mononuclear Mice T-Lymphocytes, Cytotoxic
Adult T cell leukemia Cytotoxic T cells Human T cell lymphotropic virus type-1 T cell immunotherapy Tax

Journal

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536
Titre abrégé: Biol Blood Marrow Transplant
Pays: United States
ID NLM: 9600628

Informations de publication

Date de publication:
08 2020
Historique:
received: 17 05 2019
revised: 24 03 2020
accepted: 05 04 2020
pubmed: 21 4 2020
medline: 24 6 2021
entrez: 21 4 2020
Statut: ppublish

Résumé

Adult T cell leukemia/lymphoma (ATL) is an aggressive peripheral T cell neoplasm caused by infection with human T cell lymphotropic virus type-1 (HTLV-1). Its prognosis remains extremely poor. Tax, the most important regulatory protein for HTLV-1, is associated with the aggressive proliferation of host cells and is also a major target antigen for CD8

Identifiants

DOI: 10.1016/j.bbmt.2020.04.006 PMID: 32311478
pubmed: 32311478
pii: S1083-8791(20)30215-9
doi: 10.1016/j.bbmt.2020.04.006
pii:
doi:

Substances chimiques

Gene Products, tax 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1377-1385

Informations de copyright

Copyright © 2020 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Auteurs

Koji Kawamura (K)

Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Yukie Tanaka (Y)

Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan; Division of Molecular Therapy, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Research Core, Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan.

Hideki Nakasone (H)

Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Yuko Ishihara (Y)

Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Shinichi Kako (S)

Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Seiichiro Kobayashi (S)

Division of Molecular Therapy, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Yuetsu Tanaka (Y)

Department of Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

Tsukasa Ohmori (T)

Department of Biochemistry, Jichi Medical University, Tochigi, Japan.

Kaoru Uchimaru (K)

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.

Sachiko Okamoto (S)

CDM Center, Takara Bio, Shiga, Japan.

Junichi Mineno (J)

CDM Center, Takara Bio, Shiga, Japan.

Hiroshi Shiku (H)

Department for Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan.

Satoshi Nishimura (S)

Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan; Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology, Saitama, Japan.

Yoshinobu Kanda (Y)

Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan. Electronic address: ycanda-tky@umin.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Development of a Unique T Cell Receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Development of a Unique T Cell Receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Transactivateurs › Produits du gène tax › Development of a Unique T Cell Receptor...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes du récepteur des cellules T › Development of a Unique T Cell Receptor...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Deltaretrovirus › Virus T-lymphotrope de type 1 des primates › Virus T-lymphotrope humain de type 1 › Development of a Unique T Cell Receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Development of a Unique T Cell Receptor...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Development of a Unique T Cell Receptor...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie à cellules T › Leucémie-lymphome à cellules T de l'adulte › Development of a Unique T Cell Receptor...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Development of a Unique T Cell Receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Development of a Unique T Cell Receptor...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T cytotoxiques › Development of a Unique T Cell Receptor...