Autoimmune factor XIII deficiency with unusual laboratory and clinical phenotype.
autoimmune disease
blood coagulation
factor XIII
factor XIII deficiency
hemorrhagic disorder
Journal
Journal of thrombosis and haemostasis : JTH
ISSN: 1538-7836
Titre abrégé: J Thromb Haemost
Pays: England
ID NLM: 101170508
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
17
03
2020
accepted:
19
03
2020
pubmed:
21
4
2020
medline:
15
5
2021
entrez:
21
4
2020
Statut:
ppublish
Résumé
Hemorrhagic diathesis due to anti-factor XIII (FXIII) autoantibody is a rare but severe disorder. Challenges of the diagnosis and treatment is demonstrated by the case of a 67-year-old female without previous bleeding history, who suffered a huge muscular hematoma. Without blank subtraction 18% plasma FXIII activity was measured; however, after correction for blank the activity was below the limit of detection and the lack of fibrin cross-linking in the patient's plasma confirmed the latter result. FXIII-A
Identifiants
pubmed: 32311817
doi: 10.1111/jth.14811
pii: S1538-7836(22)01438-6
doi:
Substances chimiques
Factor XIII
9013-56-3
Factor XIIIa
EC 2.3.2.13
Types de publication
Case Reports
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1330-1334Informations de copyright
© 2020 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis.
Références
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