Effects of Balneotherapy in Jeju Magma-Seawater on Knee Osteoarthritis Model.
Animals
Apoptosis
Balneology
Bone Density
Cartilage
/ pathology
Cell Proliferation
Compressive Strength
Disease Models, Animal
Inflammation
/ complications
Inflammation Mediators
/ metabolism
Knee Joint
/ pathology
Male
Matrix Metalloproteinases
/ metabolism
Osteoarthritis, Knee
/ complications
Proteolysis
RNA, Messenger
/ genetics
Rats, Sprague-Dawley
Seawater
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 04 2020
20 04 2020
Historique:
received:
22
02
2019
accepted:
10
03
2020
entrez:
22
4
2020
pubmed:
22
4
2020
medline:
27
11
2020
Statut:
epublish
Résumé
Balneotherapy is a common non-pharmacological treatment for osteoarthritis (OA), however, the efficacy is controversial in knee OA. Jeju magma-seawater (JMS) has high contents of various minerals, which has anti-inflammatory and antioxidant properties via an oral route. Thus, we examined the effects of JMS bathing on knee OA and the combination effects with diclofenac sodium as an anti-inflammatory drug. Knee OA was induced by transection of the anterior cruciate ligament and the partial meniscectomy in rat. The rats were administered subcutaneously saline or diclofenac sodium in saline, followed by bathing in thermal distilled water or JMS for 8 weeks. The model represented the characteristic changes of the cartilage degradation, osteophyte formation and synovial inflammation, and the relevant symptoms of the joint swelling and stiffness. However, the JMS bathing reduced the joint thickness and improved the mobility. It also contributed to a well-preserved tissue supported by increases in bone mineral density of the joint and decreases in Mankin scores in the cartilages. The effects involved anti-inflammation, chondroprotection, anti-apoptosis, and chondrogenesis. Overall, the JMS bathing in combination with diclofenac sodium showed a similar trend associated with synergic effects. It suggests that JMS bathing can be promising for a clinical use in knee OA.
Identifiants
pubmed: 32313003
doi: 10.1038/s41598-020-62867-2
pii: 10.1038/s41598-020-62867-2
pmc: PMC7171195
doi:
Substances chimiques
Inflammation Mediators
0
RNA, Messenger
0
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6620Références
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