Brain-synthesized oestrogens regulate cortical migration in a sexually divergent manner.
Cyp19a1
aromatase
corticogenesis
neural development
neural stem cell
radial migration
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
29
05
2019
revised:
03
04
2020
accepted:
16
04
2020
pubmed:
22
4
2020
medline:
22
6
2021
entrez:
22
4
2020
Statut:
ppublish
Résumé
Oestrogens play an important role in brain development where they have been implicated in controlling various cellular processes. Several lines of evidence have been presented showing that oestrogens can be synthesized locally within the brain. Studies have demonstrated that aromatase, the enzyme responsible for the conversion of androgens to oestrogens, is expressed during early development in both male and female cortices. Furthermore, 17β-oestradiol has been measured in foetal brain tissue from multiple species. 17β-oestradiol regulates neural progenitor proliferation as well as the development of early neuronal morphology. However, what role locally derived oestrogens play in regulating cortical migration and, moreover, whether these effects are the same in males and females are unknown. Here, we investigated the impact of knockdown expression of Cyp19a1, which encodes aromatase, between embryonic day (E) 14.5 and postnatal day 0 (P0) had on neural migration within the cortex. Aromatase was expressed in the developing cortex of both sexes, but at significantly higher levels in male than female mice. Under basal conditions, no obvious differences in cortical migration between male and female mice were observed. However, knockdown of Cyp19a1 resulted in an increase in cells within the cortical plate, and a concurrent decrease in the subventricular zone/ventricular zone in P0 male mice. Interestingly, the opposite effect was observed in females, who displayed a significant reduction in cells migrating to the cortical plate. Together, these findings indicate that brain-derived oestrogens regulate radial migration through distinct mechanisms in males and females.
Substances chimiques
Estrogens
0
Estradiol
4TI98Z838E
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2646-2663Subventions
Organisme : NIMH NIH HHS
ID : P50 MH094268
Pays : United States
Organisme : Medical Research Council
ID : MR/L021064/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG065168
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA041208
Pays : United States
Informations de copyright
© 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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